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Ricky Pearsall
Begins practice week with absence
Pearsall, who's missed the last two games due to a knee injury, wasn't able to return to practice Wednesday, Nick Wagoner of ESPN.com reports.
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George Kittle
Trending up for Sunday night
Kittle, who's been on injured reserve due to a hamstring injury since Sept. 9, had his 21-day practice window opened Wednesday and is tracking toward playing in Sunday night's Week 7 matchup against the Falcons, Nick Wagoner of ESPN.com reports.
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Mac Jones
To be limited again this week
Jones, who continues to navigate lingering knee and oblique injuries, will practice on a limited basis this week, as will Brock Purdy due to his toe injury, Nick Wagoner of ESPN.com reports.
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Brock Purdy
Gets in limited practice Wednesday
Purdy, who's missed the last two games with a toe injury, was able to practice on a limited basis Wednesday, Nick Wagoner of ESPN.com reports.
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Tatum Bethune
Chance to fill in for Warner
Bethune will be relied upon to fill the void left by Fred Warner's season-ending ankle injury, Nick Wagoner of ESPN reports.
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Brandon Aiyuk
Targeting Week 10 return
Coach Kyle Shanahan said Aiyuk could be in line for a Week 10 return, Matt Maiocco of NBC Sports Bay Area reports.
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George Kittle
Aiming for Week 7 return
Kittle is expected to return to practice Wednesday, with the goal of playing Sunday night against Atlanta, Matt Maiocco of NBC Sports Bay Area reports.
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Ricky Pearsall
Chance to return Week 7
Pearsall could return from his knee injury Week 7 against Atlanta, per Adam Schefter of ESPN.
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Brock Purdy
Could be back Week 7
Purdy has "a chance" to return from his toe injury Week 7 against the Falcons, according to Adam Schefter of ESPN.
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Ricky Pearsall
Another absence officially on tap
Pearsall will sit out Sunday's Week 6 matchup against the Buccaneers due to his knee injury, Nick Wagoner of ESPN.com reports.
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Kendrick Bourne
Another prominent role expected
Bourne, who posted a breakout 10-catch, 142-yard performance against the Rams in Week 5, is likely to operate as no less than the 49ers' No. 2 receiver for Sunday's game against the Buccaneers, Nick Wagoner of ESPN.com reports.
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Jauan Jennings
Trending toward game-time call
Jennings, who was sidelined in Week 5 due to rib and ankle injuries, is questionable for Sunday's matchup against the Buccaneers after managing to practice in limited fashion Thursday and Friday, Nick Wagoner of ESPN.com reports.
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Mac Jones
Officially Week 6 starter
Jones will draw a second consecutive start in Sunday's game against the Buccaneers due to Brock Purdy being ruled out because of his toe injury, Nick Wagoner of ESPN.com reports.
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Jauan Jennings
Chance to return Week 6
General manager John Lynch said Thursday that Jennings has a chance to return to action Sunday against the Buccaneers, Cam Inman of the Bay Area News Group reports.
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Adrian Martinez
Could take first-team reps
Martinez could take first-team reps in practice this week due to injuries to both Brock Purdy and Mac Jones, Nick Wagoner of ESPN.com reports.
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Jauan Jennings
Sits out Wednesday's practice
Jennings, who missed the 49ers' Week 5 overtime win over the Rams due to ribs and ankle injuries, remained sidelined at Wednesday's practice, Nick Wagoner of ESPN.com reports.
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George Kittle
Week 6 return not expected
Kittle, who's been sidelined for the last four games on injured reserve due to a Week 1 hamstring injury, is not expected to participate in practice this week, Nick Wagoner of ESPN.com reports.
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Ricky Pearsall
Not looking good for Week 6
Pearsall, who missed the 49ers' Week 5 overtime win over the Rams due to a knee injury, did not practice Wednesday and doesn't appear to have a good chance of playing Sunday against the Buccaneers, Nick Wagoner of ESPN.com reports. "We'll see if there's a turn here on Thursday or Friday, but I'm not counting on it right now," head coach Kyle Shanahan said of Pearsall.
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Mac Jones
Week 6 start likely
Jones appears headed for another start in Week 6 against the Buccaneers despite the fact he's dealing with both knee and oblique injuries, Nick Wagoner of ESPN.com reports.
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Brock Purdy
Remains out of practice
Purdy has yet to return to practice due to his toe injury, but the team isn't yet contemplating putting him on injured reserve, Nick Wagoner of ESPN.com reports.
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Brock Purdy
Multi-week absence on table
Purdy, who's sitting out Thursday night's game against the Rams, is considered week-to-week, Grant Gordon of NFL.com reports.
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Christian McCaffrey
Massive volume likely again
McCaffrey could see an increase in the 25 touches per game he's averaging thus far this season during Thursday night's contest against the Rams, as multiple 49ers skill-position players will be sidelined due to injury, Nick Wagoner of ESPN.com reports.
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Demarcus Robinson
Big role in second game?
Robinson, who just made his 49ers debut in Sunday's Week 4 loss to the Jaguars after serving a season-opening three-game suspension, is projected to serve as one of San Francisco's top two wide receivers in Thursday's game against the Rams, Nick Wagoner of ESPN.com reports.
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Jauan Jennings
Sitting out vs. Rams
Jennings will not play in Thursday night's Week 5 matchup against the Rams due to ankle and ribs injuries, Nick Wagoner of ESPN.com reports.
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Ricky Pearsall
Won't play Week 5
Pearsall has been ruled out for Thursday night's game against the Rams due to his knee injury, Nick Wagoner of ESPN.com reports.
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