Best 49ers vs Rams Player Prop Bet Picks for Thursday Night Football Week 5

RotoWire has the best prop bets for the 49ers vs Rams on Thursday Night Football! Find out more about our 49ers vs Rams picks for Week 5.
Best 49ers vs Rams Player Prop Bet Picks for Thursday Night Football Week 5
SPECIAL OFFER

Get 30% OFF

Take advantage of our NFL in-season tools like waiver wire, DFS Lineup Optimizer, and easy-to-use Picks. Get 30% off any subscription. Ends 10/7. Use promo code ROTO30.
PROMO CODE ROTO30

The NFC West is the most competitive division in football, with three teams sitting at 3-1. Two of those three square off on Week 5 Thursday Night Football, as the San Francisco 49ers take on the Los Angeles Rams. The NFL Week 5 odds list the Rams as whopping 7.5-point favorites over their division foes. 

If you're looking to spice up tonight's game with a few NFL Week 5 player props, I've got you covered. Just make sure you use an offer like the bet365 bonus code to maximize your picks. Here are my four favorite props to bet tonight:

Best Fanatics 49ers vs Rams Prop Bets: Week 5

Fanatics Sportsbook provides all odds in this section. Use a Fanatics Sportsbook promo to maximize your player props. 

Christian McCaffery: Rushing Yards – OVER 5 Yards (+10000)

This line is only available to new users. But if you haven't signed up for Fanatics Sportsbook, tonight is the night to do it. If superstar running back Christian McCaffery reaches 5-plus rushing yards, new users will score on a Bet $1, Get $100 in Cash deal. This is one of the best deals on the market, so make sure to claim it if you haven't signed up with Fanatics Sportsbook yet. 

Christian McCaffery: Rushing Yards – UNDER 65.5 (-120) 

He'll have no problem clearing five yards, but getting to 65 may be a different story. Despite ranking sixth in the NFL in carries, CMC has only eclipsed 65 rushing yards in one of his four starts on the year. He's averaging 56.3 on the season. It's hard to see that changing on Thursday night. The Rams allow a successful run at the 10th-lowest rate in the league, while SF has the ninth-lowest rushing success rate so far. That combination means we're likely to see a lot of losses and stuffs for CMC tonight.  

Best BetMGM 49ers vs Rams Prop Bets: Week 5

BetMGM Sportsbook provides all odds in this section. Use a BetMGM bonus code to maximize your player props. 

Puka Nacua: Receptions – OVER 7.5 (-155) 

Puka Nacua has cleared this total in every game this season. He's making it look easy, too, reaching double-digit catches in three of his four appearances. The burgeoning superstar is averaging 10.5 receptions per game for 125.8 receiving yards on 12.5 targets per outing. He shouldn't have much trouble against an average San Francisco defense that will be without its best player in Nick Bosa. 

Best DraftKings 49ers vs Rams Prop Bets: Week 5

DraftKings Sportsbook provides all odds in this section. Use a DraftKings Sportsbook promo to maximize your player props. 

Christian McCaffery: Receiving Yards – OVER 55.5 (-111) 

The 49ers are as banged up as it gets right now. This offense is going to run through CMC tonight. And as 7.5-point underdogs, this offense is going to be playing from behind. That combination should lead to a busy night for CMC in the receiving game. McCaffery has at least 52 receiving yards in all four games this season, averaging 76.3 receiving yards per contest. The Rams have allowed the second-fewest receiving yards to RBs this season (46), but there's too much working in CMC's favor to fade him tonight. 

Where to Place Thursday Night Football Prop Bets

Below, I've listed the best sportsbooks to consider for all your Thursday Night Football prop bets. I've also included the sign-up bonuses offered by each operator. 

📕 Sportsbook

💰 Welcome Offer

FanDuel SportsbookCLICK TO CLAIM: Bet $5, Get $300 in Bonus Bets If Your Bet Wins
DraftKings SportsbookCLICK TO CLAIM: Bet $5, Get $200 in Bonus Bets Instantly
Fanatics SportsbookCLICK TO CLAIM: Get Up to $100 Back in FanCash If Your Football Bet Loses
BetMGM SportsbookROTOSPORTS: $1,500 First Bet Offer
Caesars SportsbookROTO20X: Bet $1, Double Your Winnings Your Next 20 Bets
bet365 SportsbookROTOWIRE: Bet $5, Get $200 in Bonus Bets Win or Lose

RotoWire's Favorite Sportsbook Promo for TNF This Week

For my money, Fanatics Sportsbook's Bet $1, Get $100 in Cash welcome offer is the top bonus this week. But it's a limited-time offer, so make sure you claim it before it goes away! 

ABOUT THE AUTHOR
Max is currently a Senior Growth Product Strategist with RotoWire and has worked in the betting and fantasy space since 2018. Over the years, he's written numerous articles, blogs, and unanswered letters to Tom Brady. While waiting for a response from Brady, Staley has worked as a Content Strategist and Writer/Editor with bylines from RotoWire, MinuteMedia, and more. Originally from Los Angeles, he roots for the New England Patriots, Boston Celtics, and Boston Red Sox, though he now lives in Brooklyn. And he's very aware of how annoying that sentence sounds. In his downtime, he tinkers with his perfectly constructed dynasty team.

Top News

Tools

NFL Draft Kit Logo

NFL Draft Kit

Fantasy Tools

Don’t miss a beat. Check out our 2025 NFL Fantasy Football rankings.