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You can land that first-time bet early in the day on one of the MLB Playoff games and then have enough bonus bets for the NFC West showdown in primetime, featuring a pair of 3-1 teams. The Rams (-6.5) have won three straight meetings against the 49ers, who come limping into this game with Brock Purdy and a slew of skill-position players littering the injury report.
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DraftKings Promo Code | Bet $5, Get $200 in Bonus Bets Instantly
College football bettors can earn $200 in bonus bets instantly by using the DraftKings promo code on college football today! Simply place a $5 bet and you'll earn that bonus instantly, win or lose.
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MORE: Best sportsbook promos
DraftKings Promo Code Terms & Conditions
The sign-up offer from DraftKings is only available to new users who are of legal betting age who are also located in a legal sports betting state. No specific code is required, just make sure to follow our BET NOW links to get started. All you need to know from there is that you need to deposit a minimum of $10 and make that first bet of $5.
Best Bets for 49ers-Rams Thursday Night Football
Best Bets for 49ers-Rams: 2-Leg Same Game Parlay: Rams -4.5 + Over 44.5 Points (+165)
This is a terrible spot for the 49ers after just losing a home game to the Jaguars last week. Now, they'll hit the road on a short week to face a division foe (who they've lost to three straight times) with a severely banged up roster. On the other hand, the Rams coasted last week and got away with a late victory against the Colts, but they have certainly overachieved beyond expectations thus far. If it weren't for the second-half collapse in Philly, we'd be talking about the Rams trying to extend their unbeaten streak tonight.
Early on, there's a massive differential in bets (70%+ to the under) compared to the money (65% to the over), so I am immediately intrigued by this revelation. The Rams have scored 26+ points in each of their last three games, and it's worth noting that Sean McVay is 8-2 on Thursday Night Football over his career; this leads me to believe LA's offense will run smoothly, while we'll certainly need some garbage-time heroism from San Francisco to get us over the finish line. Luckily, we'll have Christian McCaffrey on our side for that.
Best Bets for 49ers-Rams: Kyren Willams – Over 70.5 Rushing Yards (-114)
We're not getting the best number on Williams' rushing yards (opened at 66.5), but there's still plenty of reasons to think he'll smash past the current 70.5. One aspect to consider is that Williams' 13 carries on Sunday were cut short to have fresher legs against the divisional-rival 49ers in a game for first place.
Williams has been wildly effective, rushing for 60+ yards in all but two of his last 22 games played! San Fran gave up 4.7 yards per carry last week to Jacksonville, and I don't see that improving in a short-week game on the road.
Thursday Night Football Picks
- 2-Leg SGP: Rams -4.5 + Over 44.5 Points (+165)
- Kyren Williams: Over 70.5 Rushing Yards (-114)
Best Events to Use the DraftKings Promo Code for Thursday, October 2, 2025
- NFL: San Francisco 49ers at Los Angeles Rams, 8:15 p.m. ET | The 49ers hit the road for an early-week primetime showdown in LA with the Rams for first place in the NFC West.
- College Football: Sam Houston at New Mexico State, 9 p.m. ET | You can bet on tonight's matchup at one of the top sites for college football betting.
- MLB: Detroit Tigers at Cleveland Guardians, 1 p.m. ET | Bet on today's winner-take-all matchups with one of the top MLB betting promos.
- MLB: San Diego Padres at Chicago Cubs, 3 p.m. ET
- MLB: Boston Red Sox at New York Yankees, 6 p.m. ET
- MLB: Cincinnati Reds at Los Angeles Dodgers, 9 p.m. ET
