San Francisco 49ers vs Jacksonville Jaguars Odds, Week 4, 2025

#1 LDE

Mykel Williams: Practices in full

Sep 24th

Williams logged a full practice session Wednesday, Matt Barrows of The Athletic reports.

#1 RCB

Deommodore Lenoir: Limited by illness

Sep 24th

Lenoir (illness) logged a limited practice Wednesday, Matt Barrows of The Athletic reports.

#1 LCB

Renardo Green: Turns in limited session

Sep 24th

Green (neck) logged a limited practice Wednesday, Matt Barrows of The Athletic reports.

#7 WR

Jordan Watkins: No practice Wednesday

Sep 24th

Watkins (calf) did not practice Wednesday, Matt Barrows of The Athletic reports.

#2 QB

Mac Jones: Limited Wednesday

Sep 24th

Coach Kyle Shanahan said Jones (knee) will be a limited practice participant Wednesday, Matt Barrows of The Athletic reports.

#2 WR

Ricky Pearsall: Not practicing Wednesday

Sep 24th

Pearsall will miss Wednesday's practice due to a knee injury, David Lombardi of SFStandard.com reports.

#1 QB

Brock Purdy: To be limited Wednesday

Sep 24th

Coach Kyle Shanahan said Purdy (left shoulder/toe) will be limited at Wednesday's practice, Matt Barrows of The Athletic reports.

#1 WR

Jauan Jennings: Not practicing Wednesday

Sep 24th

Jennings (ankle/shoulder) is not participating in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.

#1 WLB

Dee Winters: Plays every defensive snap Week 3

Sep 23rd

Winters logged eight tackles (four solo) and a pass defense during the 49ers' 16-15 win over the Cardinals on Sunday.

#2 DT2

CJ West: Requires surgery on thumb

Sep 22nd

Head coach Kyle Shanahan relayed Monday that West will need to undergo surgery to repair a broken thumb, Eric Branch of the San Francisco Chronicle reports.

#4 RDE

Nick Bosa: ACL tear confirmed

Sep 22nd

Coach Kyle Shanahan confirmed Monday that Bosa is out for the season with an ACL injury, Cam Inman of The San Jose Mercury News reports.

#4 WR

Demarcus Robinson: Suspension lifted

Sep 22nd

Robinson's suspension has been lifted by the NFL, which sets the stage for the wideout to be available for Sunday's game against the Jaguars, Aaron Wilson of KPRC 2 Houston reports.

#1 TE

Jake Tonges: Gains 21 yards in start

Sep 22nd

Tonges brought in two of three targets for 21 yards in Sunday's 16-15 win over the Cardinals.

#6 WR

Skyy Moore: Gets involved on offense Sunday

Sep 22nd

Moore brought in his only target for 10 yards in Sunday's 16-15 win over the Cardinals.

#5 WR

Marquez Valdes-Scantling: First reception with SF

Sep 22nd

Valdes-Scantling had one reception for nine yards in Sunday's 16-15 win over Arizona.

#3 WR

Kendrick Bourne: Nabs four receptions in spot-start

Sep 22nd

Bourne had four receptions (on six targets) for 38 yards in Sunday's 16-15 win over Arizona.

#1 MLB

Fred Warner: Logs 11 stops in Week 3

Sep 22nd

Warner tallied 11 total tackles (five solo) and two passes defended during Sunday's 16-15 win over the Cardinals.

#3 RB

Isaac Guerendo: Stuck on special teams

Sep 22nd

Guerendo did not receive a carry while gaining 19 yards on a kickoff return in Sunday's 16-15 win over the Cardinals.

#2 RB

Brian Robinson: Drop in usage Sunday

Sep 22nd

Robinson had two carries for 22 yards and was not targeted as a receiver in Sunday's 16-15 win over Arizona.

#1 K

Eddy Pineiro: Nails game-winning field goal

Sep 21st

Pineiro hit all three field-goal tries, including a 35-yarder as time expired, and his only extra-point attempt in Sunday's 16-15 win over the Cardinals.

#1 RB

Christian McCaffrey: Cracks century mark in total yards

Sep 21st

McCaffrey rushed 17 times for 52 yards while corralling 10 of 15 targets for 88 yards in Sunday's 16-15 victory over the Cardinals.

#1 LG

Connor Colby: Will start for SF on Sunday

Sep 21st

Colby (groin) is active for Sunday's Week 3 clash against the Cardinals, Briana Jeannel of the 49ers' official site reports.

#4 RB

Jordan James: Won't play against Arizona

Sep 21st

James (coach's decision) is inactive for Sunday's game against the Cardinals, Briana Jeannel of the 49ers' official site reports.

#2 LT

Spencer Burford: Lands on IR

Sep 20th

Burford (knee) was placed on injured reserve Saturday.

#2 FS

Siran Neal: Clears concussion protocol

Sep 19th

Neal does not have an injury designation for Sunday's game against the Cardinals, Tyler Drake of ArizonaSports.com reports.

#1 FB

Kyle Juszczyk: Clears concussion protocol

Sep 19th

Juszczyk does not have an injury designation ahead of Sunday's matchup against the Cardinals, Tyler Drake of ArizonaSports.com reports.

#2 LDE

Yetur Gross-Matos: Taken off injury report

Sep 19th

Gross-Matos does not have an injury designation ahead of Sunday's game against the Cardinals, Tyler Drake of ArizonaSports.com reports.

#2 LG

Ben Bartch: Lands on IR

Sep 17th

Bartch (ankle) was placed on injured reserve Wednesday, Noah Furtado of the San Francisco Chronicle reports.

#8 WR

Brandon Aiyuk: Spotted running

Sep 17th

Aiyuk (knee) did some running while his teammates were practicing Wednesday, Nick Wagoner of ESPN.com reports.

#3 TE

Brayden Willis: Bumps to active roster

Sep 17th

The 49ers signed Willis to the active roster from the practice squad Wednesday.

#2 TE

Luke Farrell: Scores first TD of career

Sep 15th

Farrell brought in two of three targets for 15 yards and a touchdown in Sunday's 26-21 win over the Saints.

#1 LT

Trent Williams: Suiting up Sunday

Sep 14th

Williams (knee) is active for Sunday's matchup with the Saints, Briana Jeannel of the 49ers' official site reports.