Bills vs Chiefs Odds, Lines, Spreads & Totals 2025
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ESPN Bet 
Hard Rock 
Chiefs
23.0 Pts
Bills
25.5 Pts
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Moneyline
DraftKings
PROBABILITY with vig removed
Chiefs Win (+114)
44.9%
Bills Win (-135)
55.1%
LINE MOVEMENT
No changes have been recorded yet.
No changes have been recorded yet.
Spread
DraftKings
PROBABILITY with vig removed
Win or Lose By < 3 Pts(-110)
50.0%
Win By 3+ Pts(-110)
50.0%
LINE MOVEMENT
No changes have been recorded yet.
No changes have been recorded yet.
No changes have been recorded yet.
Over Under
DraftKings Points
PROBABILITY with vig removed
Over 49 Total Points(-110)
50.0%
Under 49 Total Points(-110)
50.0%
LINE MOVEMENT
No changes have been recorded yet.
No changes have been recorded yet.
No changes have been recorded yet.
Player Props
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Chiefs Injury Report
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Bills Injury Report
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Chiefs Lineup
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QB
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RB
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WR
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WR
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WR
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TE
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K
Inactives
None reported yet.
Bills Lineup
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QB
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RB
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WR
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WR
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WR
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TE
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K
Inactives
None reported yet.
Chiefs News
#6 WR
Skyy Moore: Taking part in OTAs
May 30th
Moore (abdomen) has been participating in Chiefs' OTAs this week, John Dillon of Chiefs Wire reports.
#1 RB
Isiah Pacheco: Adds weight, looking healthy
May 29th
Chiefs head coach Andy Reid said Thursday that Pacheco "looks tremendous" at OTAs and has "put on some good weight," Charles Goldman of AtoZSports.com reports.
#1 WR
Rashee Rice: Absent due to illness
May 29th
Chiefs head coach Andy Reid said Thursday that Rice (knee) is "under the weather" and has been instructed to remain away from the team for this week of voluntary OTAs, Charles Goldman of AtoZSports.com reports.
#2 LT
Josh Simmons: Recovery going well
May 29th
Head coach Andy Reid told reporters Thursday that Simmons (knee) is "further ahead than [he] thought" in his recovery process, Charles Goldman of AtoZSports.com reports.
#1 LG
Mike Caliendo: Starting in 2025?
May 29th
Head coach Andy Reid told reporters Thursday that Caliendo is competing with Kingsley Suamataia for the team's top left guard spot ahead of the 2025 season, Charles Goldman of AtoZSports.com reports.
Bills News
#5 WR
Curtis Samuel: Ready to bounce back?
May 30th
Bills head coach Sean McDermott said Wednesday he has a "better understanding" of how Samuel "can help us and the role that he may play for us" entering Year 2 with the team, Ralph Ventre of SI.com reports.
#2 RB
Ray Davis: Taking advantage of Cook's absence
May 30th
Davis took first-team running back reps at Thursday's voluntary team activities with James Cook absent, Lance Lysowski of The Buffalo News reports.
#4 QB
Shane Buechele: Participating in OTAs
May 28th
Buechele (neck) participated during OTAs on Tuesday.
#1 RDE
Joey Bosa: Dealing with calf issue
May 27th
Coach Sean McDermott said Tuesday that Bosa will not participate in offseason workouts this spring due to a calf injury, Jay Skurski of The Buffalo News reports.
#1 RB
James Cook: Not at voluntary OTAs
May 27th
Cook wasn't present for Tuesday's voluntary organized team activities, Alaina Getzenberg of ESPN reports.