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Cardinals vs 49ers Odds, Lines, Spreads & Totals 2025

49ers
25.5 Pts
Cardinals
23.0 Pts
Sunday November 16, 2025 at 4:05 PM ET
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49ers Injury Report
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Cardinals Injury Report
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49ers Lineup
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Cardinals Lineup
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49ers News
#1 SS
Ji'Ayir Brown: Notches double-digit tackles
Nov 10th
Brown recorded 10 tackles (three solo) and one pass defensed in Sunday's 42-26 loss to the Rams.
#1 MLB
Tatum Bethune: Double-digit stops again
Nov 10th
Bethune recorded 10 tackles (two solo), including one tackle for loss in Sunday's 42-26 loss to the Rams.
#7 WR
Brandon Aiyuk: Unlikely to practice this week
Nov 10th
Coach Kyle Shanahan said Monday that the 49ers don't intend to open Aiyuk's (knee) practice window this week, Nick Wagoner of ESPN.com reports.
#2 WR
Ricky Pearsall: May practice Wednesday
Nov 10th
Coach Kyle Shanahan said Monday that Pearsall (knee) has a chance to practice Wednesday, Matt Barrows of The Athletic reports.
#1 QB
Brock Purdy: Increasing odds to return to action
Nov 10th
Coach Kyle Shanahan said Monday that Purdy (toe) will continue to increase his activity level this week, Nick Wagoner of ESPN.com reports.
#2 TE
Luke Farrell: Hits pay dirt in loss
Nov 10th
Farrell had two receptions on as many targets for 15 yards and a touchdown in Sunday's 42-26 loss to the Rams.
#6 WR
Jordan Watkins: No targets against Rams
Nov 10th
Watkins was limited to three snaps on offense (five percent) and did not garner a target in Sunday's 42-26 loss to the Rams.
#5 WR
Skyy Moore: Reception in consecutive games
Nov 10th
Moore secured his only target for 18 yards in Sunday's 42-26 loss to the Rams.
#4 WR
Demarcus Robinson: Gets involved Sunday
Nov 10th
Robinson had three receptions on four targets for 34 yards in Sunday's 42-26 loss to the Rams.
#3 WR
Kendrick Bourne: Held to one catch in Sunday's start
Nov 10th
Bourne caught his only target for 19 yards in Sunday's 42-26 loss to the Rams.
#2 RB
Brian Robinson: Scores in consecutive games
Nov 9th
Robinson took eight carries for 41 yards and a touchdown while catching his only target for four yards in Sunday's 42-26 loss to the Rams.
#1 TE
George Kittle: Best fantasy game this season
Nov 9th
Kittle secured all nine of his targets for 84 yards and a touchdown in Sunday's 42-26 loss to the Rams.
#1 WR
Jauan Jennings: Best line since Week 2
Nov 9th
Jennings corralled six of nine targets for 71 yards and a touchdown while losing a fumble in Sunday's 42-26 loss to the Rams.
#2 QB
Mac Jones: Strong fantasy performance Sunday
Nov 9th
Jones completed 33 of 39 pass attempts for 319 yards, three touchdowns and one interception while gaining three yards on one rush attempt in Sunday's 42-26 loss to the Rams.
#1 RB
Christian McCaffrey: Grinds for 96 total yards Sunday
Nov 9th
McCaffrey rushed 12 times for 30 yards and brought in eight of 10 targets for 66 yards in Sunday's 42-26 loss to the Rams.
#1 K
Eddy Pineiro: Limited workload in loss
Nov 9th
Pineiro did not attempt a field goal and went 2-for-3 on extra-point tries in Sunday's 42-26 loss to the Rams.
#2 LDE
Keion White: Cleared to play vs. Rams
Nov 9th
White (groin) is active for Sunday's game against the Rams, Briana Jeannel of the 49ers' official site reports.
#1 DT2
Alfred Collins: Won't play Week 10
Nov 9th
Collins (hip) is inactive for Sunday's game against the Rams, Briana Jeannel of the 49ers' official site reports.
#1 LG
Ben Bartch: Officially returning in Week 10
Nov 9th
Bartch (ankle) is active for Sunday's battle against the Rams, Briana Jeannel of the 49ers' official site reports.
#1 LDT
Kalia Davis: Will play Week 10
Nov 9th
Davis (ankle) is active for Sunday's game against the Rams, Briana Jeannel of the 49ers' official site reports.
#1 WLB
Dee Winters: Green light to play Week 10
Nov 9th
Winters (knee) is active for Sunday's game against the Rams, Briana Jeannel of the 49ers' official site reports.
#4 RDE
Mykel Williams: Sent to injured reserve
Nov 8th
The 49ers placed Williams (knee) on injured reserve Saturday.
#1 C
Jake Brendel: Returning to action in Week 10
Nov 7th
Brendel (hamstring) does not have an injury designation for Sunday's battle against the Rams, Nick Wagoner of ESPN.com reports.
#1 LDE
Bryce Huff: Cleared to return Week 10
Nov 7th
Huff (hamstring) does not carry an injury designation into Sunday's game against the Rams, Matt Barrows of The Athletic reports.
#2 DT2
Jordan Elliott: Cleared to play Week 9
Nov 2nd
Elliott (ankle) is active for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports.
#2 LG
Spencer Burford: Officially cleared for Week 9
Nov 2nd
Burford (knee) is active for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports.
#2 LT
Spencer Burford: Officially cleared for Week 9
Nov 2nd
Burford (knee) is active for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports.
#2 FS
Marques Sigle: Healthy scratch Sunday
Nov 2nd
Sigle (coach's decision) is inactive for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports.
#1 RDE
Sam Okuayinonu: Good to go Sunday
Nov 2nd
Okuayinonu (ankle) is active for Sunday's matchup with the Giants, Briana Jeannel of the 49ers' official site reports.
#3 RDE
Yetur Gross-Matos: Lands on IR
Nov 1st
Gross-Matos (knee) was placed on injured reserve Saturday.
#1 SCB
Upton Stout: Cleared for Week 9
Oct 31st
Stout (shoulder) has no injury designation ahead of Sunday's game against the Giants.
#1 LCB
Renardo Green: Posts eight stops vs. Houston
Oct 30th
Green registered eight tackles (four solo) during the 49ers' 26-15 loss to the Texans on Sunday.
#1 RCB
Deommodore Lenoir: Haults in first INT of 2025
Oct 30th
Lenoir registered three tackles (two solo) and one interception during the 49ers' 26-15 loss to the Texans on Sunday.
#3 TE
Jake Tonges: Scores, but plays just five snaps
Oct 29th
Tonges recorded a two-yard touchdown reception on his lone target while playing five of the 49ers' 48 snaps on offense in Sunday's 26-15 loss to the Texans.
#3 RB
Isaac Guerendo: No run on offense this season
Oct 29th
Guerendo played all 10 of his snaps on special teams in Sunday's 26-15 loss to the Texans.
#1 FS
Malik Mustapha: Season-high stops in Week 8 loss
Oct 28th
Mustapha made 12 tackles (six solo) during Sunday's loss to the Texans.
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Cardinals News
#2 RCB
Denzel Burke: Picks off Darnold in Week 10 loss
Nov 10th
Burke recorded five tackles (four solo) and an interception during the Cardinals' 44-22 loss to the Seahawks on Sunday.
#6 WR
Simi Fehoko: Expected to miss time with injury
Nov 10th
Head coach Jonathan Gannon said Monday that Fehoko is expected to "miss some time" due to a wrist injury he sustained against the Seahawks on Sunday, Tyler Drake of ArizonaSports.com reports.
#5 WR
Zay Jones: To be placed on IR
Nov 10th
Coach Jonathan Gannon said Monday that Jones will be placed on injured reserve due to an Achilles injury, Bo Brack of GoPHNX.com reports.
#1 WR
Marvin Harrison: Inefficient with TD scored
Nov 9th
Harrison had three receptions on 12 targets for 33 yards and a touchdown in Sunday's 44-22 loss to Seattle.
#2 RB
Emari Demercado: Goes for over 100 total yards
Nov 9th
Demercado took four carries for 64 yards while catching three of four targets for 40 yards in Sunday's 44-22 loss to Seattle.
#1 QB
Jacoby Brissett: Mixed results in blowout loss
Nov 9th
Brissett completed 22 of 44 pass attempts for 258 yards and two touchdowns while gaining 31 yards on four carries and losing two fumbles in Sunday's 44-22 loss to Seattle.
#1 K
Chad Ryland: No FGAs in loss
Nov 9th
Ryland did not attempt a field goal and made both of his PATs in Sunday's 44-22 loss to the Seahawks.
#1 TE
Trey McBride: Goes off against SEA
Nov 9th
McBride finished with nine receptions on 13 targets for 127 yards and a touchdown in Sunday's 44-22 loss to the Seahawks.
#2 DT2
Walter Nolen: Exits early Sunday
Nov 9th
Nolen (knee) has been ruled out for the rest of Sunday's contest against the Seahawks.
#1 RDE
Darius Robinson: Suffers groin injury
Nov 9th
Robinson exited Sunday's game against the Seahawks with a groin injury and will not return, Darren Urban of the Cardinals' official site reports.
#1 RB
Bam Knight: Picks up ankle injury in Week 10
Nov 9th
Knight sustained an ankle injury during Sunday's contest at Seattle.
#1 RT
Jonah Williams: Questionable to return
Nov 9th
Williams (shoulder) is questionable to return to Arizona's matchup versus the Seahawks on Sunday.
#2 SS
Dadrion Taylor-Demerson: Won't return Sunday
Nov 9th
Taylor-Demerson (ankle) has been ruled out for the rest of Sunday's game against the Seahawks.
#1 RG
Will Hernandez: Active Sunday
Nov 9th
Hernandez (knee) is active for Sunday's game against the Seahawks.
#2 FS
Kitan Crawford: Green light to play Week 10
Nov 9th
Crawford (ankle) is active for Sunday's game against Seattle.
#4 WR
Xavier Weaver: Won't play Week 10
Nov 9th
Weaver (ankle) is inactive for Sunday's game against the Seahawks.
#3 QB
Kyler Murray: Future in Arizona in limbo
Nov 9th
Murray, who was placed on injured reserve Wednesday due to a mid-foot sprain, is not expected to start again if he returns this season, "absent injury to Jacoby Brissett," Ian Rapoport of NFL Network reports.
#3 RB
Michael Carter: Joins active roster
Nov 8th
The Cardinals signed Carter from the practice squad to the active roster Saturday, Darren Urban of the team's official site reports.
#3 SLB
BJ Ojulari: Staying on PUP list
Nov 7th
Ojulari (knee) has been ruled out for Sunday's game against the Seahawks, Tyler Drake of ArizonaSports.com reports.
#1 FS
Budda Baker: Cleared to play Week 10
Nov 7th
Baker (hamstring) does not carry an injury designation into Sunday's game against the Seahawks, Tyler Drake of ArizonaSports.com reports.
#1 LCB
Will Johnson: Out for Week 10
Nov 7th
Johnson (back) has been ruled out ahead of Sunday's matchup against the Seahawks, Darren Urban of the Cardinals' official site reports.
#1 RCB
Max Melton: Out for Week 10
Nov 7th
Melton (concussion) has been ruled out ahead of Sunday's matchup against the Seahawks, Darren Urban of the Cardinals' official site reports.
#1 MLB
Mack Wilson: Won't play Sunday
Nov 7th
Wilson (ribs) has been ruled out ahead of Sunday's matchup against the Seahawks, Darren Urban of the Cardinals' official site reports.
#3 TE
Josiah Deguara: Back with Cards
Nov 5th
Arizona signed Deguara on Wednesday.
#4 RB
Trey Benson: Not practicing Wednesday
Nov 5th
Cardinals coach Jonathan Gannon said Wednesday that Benson (knee) is "doing well" but isn't ready to practice, Theo Mackie of The Arizona Republic reports.
#2 TE
Elijah Higgins: Records three receptions Monday
Nov 4th
Higgins recorded three catches (on three targets) for 30 yards during Monday's 27-17 win in Dallas.
#2 WR
Michael Wilson: Reels in three passes in Week 9
Nov 4th
Wilson hauled in three of four targets for 61 yards during Monday's 27-17 win at Dallas.
#2 MLB
Cody Simon: Ready to face Cowboys
Nov 3rd
Simon (illness) is active for Monday's game against the Cowboys, Darren Urban of the Cardinals' official site reports.
#1 SCB
Garrett Williams: Activated from IR, playing Monday
Nov 3rd
The Cardinals activated Williams (knee) from injured reserve, and he is active for Monday's game against the Cowboys, Darren Urban of the Cardinals' official site reports.