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Panthers vs Bills Odds, Lines, Spreads & Totals 2025

Bills
Panthers
Sunday October 26, 2025 at 1:00 PM ET
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BUF
Bills Injury Report
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CAR
Panthers Injury Report
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BUF
Bills Lineup
Inactives
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CAR
Panthers Lineup
Inactives
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BUF
Bills News
#2 LDE
A.J. Epenesa: Questionable for Week 4
Sep 26th
Epenesa (pectoral) is questionable for Sunday's game against the Saints.
#1 LDT
Ed Oliver: Ruled out for Week 4
Sep 26th
Oliver (ankle) has been ruled out for Sunday's game against the Saints, Alaina Getzenberg of ESPN.com reports.
#1 WLB
Matt Milano: Ruled out for Week 4
Sep 26th
Milano (pectoral) has been ruled out for Sunday's game against the Saints, Alaina Getzenberg of ESPN.com reports.
#2 K
Tyler Bass: Recovering well
Sep 24th
Head coach Sean McDermott told reporters Wednesday that Bass (left hip/groin) is moving in the right direction, but the Bills remain unsure about when he will return from injured reserve, Maddy Glab of the team's official site reports.
#1 SCB
Taron Johnson: Leads team with eight stops Week 3
Sep 22nd
Johnson posted eight tackles (six solo) and a defensed pass in Thursday's 31-21 win against the Dolphins.
#1 LCB
Tre'Davious White: Records five stops in Week 3
Sep 22nd
White totaled five tackles (four solo) and a defensed pass in a 31-21 win over Miami on Thursday.
#1 FS
Cole Bishop: Logs five stops in Week 3 win
Sep 22nd
Bishop tallied five tackles (four solo) in Thursday's 31-21 victory over Miami.
#2 TE
Dawson Knox: Blanked in Week 3
Sep 19th
Knox wasn't targeted during Thursday night's 31-21 win over the Dolphins.
#5 WR
Tyrell Shavers: Catches two passes in win
Sep 19th
Shavers caught both of his targets for 24 yards in the Bills' win over the Dolphins on Thursday night.
#4 WR
Elijah Moore: Catches two passes in TNF victory
Sep 19th
Moore caught two of three targets for 30 yards in Buffalo's 31-21 win over the Dolphins on Thursday night. He added one rush for 11 yards.
#2 RB
Ray Davis: Doesn't touch ball against Miami
Sep 19th
Davis failed to record a touch on offense in Buffalo's 31-21 win over the Dolphins on Thursday night.
#3 RB
Ty Johnson: Totals 21 yards in TNF win
Sep 19th
Johnson rushed three times for 13 yards and caught one pass for eight yards in Buffalo's win over Miami on Thursday night.
#3 WR
Joshua Palmer: One catch Thursday
Sep 19th
Palmer was on the field for 26 of a possible 60 snaps on offense in Thursday's 31-21 win over the Dolphins.
#1 TE
Dalton Kincaid: Paces pass catchers in Week 3 win
Sep 18th
Kincaid secured five of six targets for 66 yards and a touchdown in the Bills' 31-21 win over the Dolphins on Thursday night.
#1 WR
Keon Coleman: Three catches in Week 3 win
Sep 18th
Coleman secured three of four targets for 20 yards in the Bills' 31-21 win over the Dolphins on Thursday night.
#2 WR
Khalil Shakir: Scores first TD of season Thursday
Sep 18th
Shakir brought in all four targets for 45 yards and a touchdown during the Bills' 31-21 win over the Dolphins on Thursday night.
#1 RB
James Cook: Eclipses 100 total yards in win
Sep 18th
Cook rushed 19 times for 108 yards and a touchdown and brought in all three targets for 10 yards in the Bills' 31-21 win over the Dolphins on Thursday night.
#1 QB
Josh Allen: Highly efficient in Week 3 win
Sep 18th
Allen completed 22 of 28 passes for 213 yards with three touchdowns and no interceptions while adding four rushes for 25 yards in the Bills' 31-21 win over the Dolphins on Thursday night. He also fumbled once but recovered.
#1 MLB
Terrel Bernard: Seals win with pick
Sep 18th
Bernard finished with seven tackles (five solo), including one for a loss, and an interception in the Bills' 31-21 win over the Dolphins on Thursday night.
#1 K
Matt Prater: Imperfect in Week 3
Sep 18th
Prater went 1-for-2 on field-goal tries and made four PATs in Thursday's 31-21 win over the Dolphins.
#2 SCB
Cam Lewis: Suiting up against Miami
Sep 18th
Lewis (shoulder) is active for Thursday's game against the Dolphins.
#2 WLB
Shaq Thompson: Back in action
Sep 18th
Thompson (hand/hamstring) is active for Thursday's game against the Dolphins.
#6 WR
Curtis Samuel: Inactive again
Sep 18th
Samuel (coach's decision) is inactive for Thursday night's game against the Dolphins.
#4 SCB
Jordan Hancock: Trending toward Week 3 debut
Sep 15th
Hancock (shoulder) was listed as a full participant in Monday's walkthrough practice, Alec White of the Bills' official site reports.
#1 LDE
Greg Rousseau: Cleared for takeoff against Jets
Sep 12th
Rousseau (knee) doesn't have an injury designation for Sunday's game against the Jets.
CAR
Panthers News
#1 TE
Ja'Tavion Sanders: Ruled out this week
Sep 26th
Sanders (ankle) has been ruled out for Sunday's game at New England.
#1 SLB
D.J. Wonnum: Out for Week 4
Sep 26th
Wonnum (hip) has been ruled out ahead of Sunday's matchup against the Patriots.
#2 LDE
Tershawn Wharton: Questionable for Sunday
Sep 26th
Wharton (hamstring) is listed as questionable ahead of Sunday's matchup against the Patriots.
#3 WR
Xavier Legette: Out Sunday
Sep 26th
Legette (hamstring) won't play Sunday against the Patriots.
#1 WR
Tetairoa McMillan: Deemed questionable, plans to play
Sep 26th
McMillan (calf) is listed as questionable for Sunday's game against New England.
#1 WLB
Patrick Jones: Out again in Week 4
Sep 26th
Jones (hamstring) has been ruled out ahead of Sunday's matchup against the Patriots.
#1 RB
Chuba Hubbard: Listed as questionable
Sep 26th
Hubbard (calf) is listed as questionable for Sunday's game against New England.
#8 WR
Jalen Coker: Still week-to-week
Sep 24th
Coker (quadriceps) is making progress but is still considered week-to-week, Joe Person of The Athletic reports.
#1 LILB
Christian Rozeboom: Leads Carolina with nine tackles
Sep 23rd
Rozeboom registered nine tackles (six solo) during the Panthers' 30-0 win over the Falcons on Sunday.
#1 SS
Tre'von Moehrig: Six tackles vs. Atlanta
Sep 23rd
Moehrig logged six tackles (four solo) during the Panthers' 30-0 win over the Falcons on Sunday.
#3 C
Austin Corbett: Returning in 6-8 weeks
Sep 22nd
Head coach Dave Canales told reporters Monday that Corbett (knee) is expected to return in 6-8 weeks, Joe Person of The Athletic reports.
#2 RG
Robert Hunt: Done for the season?
Sep 22nd
Head coach Dave Canales told reporters Monday that Hunt could miss the rest of the season after undergoing successful surgery to repair a torn biceps, Joe Person of The Athletic reports.
#1 LCB
Mike Jackson: Continues to impress Sunday
Sep 22nd
Jackson recorded six total tackles (five solo) and one interception during Sunday's 30-0 win over the Falcons.
#1 SCB
Chau Smith-Wade: First career pick-six in Week 3
Sep 22nd
Smith-Wade recorded five total tackles (all solo) and one pick-six during Sunday's 30-0 win over the Falcons.
#4 WR
David Moore: Minimal output in win
Sep 22nd
Moore caught his only target for five yards in Sunday's 30-0 win over the Falcons.
#5 WR
Brycen Tremayne: Two grabs vs. Atlanta
Sep 22nd
Tremayne caught both of his targets for 15 yards in Sunday's 30-0 win over the Falcons.
#2 TE
Tommy Tremble: Quiet in Week 3
Sep 22nd
Tremble caught both of his targets for 16 yards in Sunday's 30-0 win over the Falcons.
#2 WR
Hunter Renfrow: Held to six yards
Sep 21st
Renfrow recorded two catches on four targets for six yards in Sunday's 30-0 win over Atlanta.
#2 RB
Rico Dowdle: Role keeps growing
Sep 21st
Dowdle recorded 10 rushes for 30 yards and a touchdown in Sunday's 30-0 win over the Falcons. He added one reception on one target for eight yards as well as one kick return for 21 yards.
#1 QB
Bryce Young: Manages Carolina to win
Sep 21st
Young completed 16 of 24 passes for 121 yards with no touchdowns or interceptions in Sunday's 30-0 win over the Falcons. He added two rushes for eight yards and a touchdown.
#1 K
Ryan Fitzgerald: Makes three field goals in win
Sep 21st
Fitzgerald went 3-for-3 on field-goal attempts and made three PATs in Sunday's 30-0 win over the Falcons.
#6 WR
Jimmy Horn: Healthy scratch again
Sep 21st
Horn (coach's decision) is inactive for Sunday's game against the Falcons, Darin Gantt of the Panthers' official site reports.
#1 NT
Bobby Brown: Ready for Sunday
Sep 19th
Brown (knee) has no injury designation ahead of Sunday's matchup against the Falcons.
#3 RB
Trevor Etienne: Just two snaps in Week 2
Sep 15th
Etienne caught one pass for two yards in Sunday's 27-22 loss to the Cardinals.
#7 WR
Dalevon Campbell: Healthy scratch Week 2
Sep 14th
Campbell (coach's decision) is inactive for Sunday's game against the Cardinals, Joe Person of The Athletic reports.
#1 LT
Ikem Ekwonu: Officially active Sunday
Sep 14th
Ekwonu (appendectomy) is active for Sunday's Week 2 game against Arizona.