Panthers vs Bills Odds, Lines, Spreads & Totals 2025
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BetMGM 
BetRivers 
Caesars 
ESPN Bet 
Hard Rock 
Bills
27.3 Pts
Panthers
20.3 Pts
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Moneyline
DraftKings
PROBABILITY with vig removed
Bills Win (-305)
72.2%
Panthers Win (+245)
27.8%
LINE MOVEMENT
Spread
DraftKings
PROBABILITY with vig removed
Win By 7+ Pts(-110)
50.0%
Win or Lose By < 7 Pts(-110)
50.0%
LINE MOVEMENT
No changes have been recorded yet.
No changes have been recorded yet.
No changes have been recorded yet.
Over Under
DraftKings Points
PROBABILITY with vig removed
Over 48 Total Points(-110)
50.0%
Under 48 Total Points(-110)
50.0%
LINE MOVEMENT
No changes have been recorded yet.
No changes have been recorded yet.
No changes have been recorded yet.
Player Props
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Bills Injury Report
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Panthers Injury Report
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Bills Lineup
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TE
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Inactives
None reported yet.
Panthers Lineup
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QB
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RB
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WR
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WR
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WR
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TE
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Inactives
None reported yet.
Bills News
#2 LDT
Deone Walker: Healthy in rookie camp
May 10th
Walker, who is in rookie camp this week, revealed that he played the 2024 season with a back injury, Alec White and Maddy Glab of the Bills' official site report. "I had a pars defect in my back," Walker said on the night of the 2025 NFL Draft. "I didn't know about it until after the season, really until the combine. We didn't really know what it was, but I feel a 100 percent right now."
Panthers News
#3 LDE
Popo Aumavae: Reverts to IR
May 9th
Aumavae (Achilles) cleared waivers and reverted to injured reserve Friday, Aaron Wilson of KPRC 2 Houston reports.
#7 RB
Jonathon Brooks: Won't play in 2025 after PUP move
May 8th
The Panthers are placing Brooks on the physically unable to perform list, ruling him out for the entire 2025 season.