Menu
Fantasy Home
NFL Betting

Texans vs 49ers Odds, Lines, Spreads & Totals 2025

49ers
Texans
Sunday October 26, 2025 at 1:00 PM ET
Loading Possible Bets...
Player Props
Loading Advanced NFL Stats...
SF
49ers Injury Report
Loading 49ers Injuries...
HOU
Texans Injury Report
Loading Texans Injuries
SF
49ers Lineup
Inactives
HOU
Texans Lineup
Inactives
SF
49ers News
#5 WR
Jordan Watkins: Not playing Week 1
Sep 7th
Watkins (ankle) has been ruled out for Sunday's game against the Seahawks.
#4 RB
Jordan James: Not playing vs. Seattle
Sep 7th
James (finger) is inactive for Sunday's game against the Seahawks.
#1 RB
Christian McCaffrey: Suiting up in season opener
Sep 7th
McCaffrey (calf) is active for Sunday's game against the Seahawks.
#1 FS
Marques Sigle: Gets starting nod Week 1
Sep 7th
Sigle will be the 49ers' starting safety against the Seahawks on Sunday, Matt Maiocco of NBC Sports Bay Area reports.
#6 WR
Russell Gage: Bumps up from practice squad
Sep 6th
The 49ers elevated Gage (knee) from the practice squad to the active roster ahead of Sunday's game at Seattle.
#1 RG
Dominick Puni: Ready to face Seahawks
Sep 5th
Puni (knee) does not have an injury designation ahead of Sunday's game against the Seahawks, Michael-Shawn Dugar of The Athletic reports.
#2 LDE
Yetur Gross-Matos: Cleared for Week 1
Sep 5th
Gross-Matos (knee) does not have an injury designation ahead of Sunday's game against the Seahawks, Michael-Shawn Dugar of The Athletic reports.
#1 WR
Jauan Jennings: Week 1 appearance on tap
Sep 5th
Coach Kyle Shanahan said Friday that Jennings (calf) is "good to go" for Sunday's contest at Seattle, Cam Inman of The San Jose Mercury News reports. "He's had a real good week," Shanahan added. "[He's] gotten better and better throughout the week, and I'm excited to see him out there Sunday."
#1 LG
Ben Bartch: Full practice Wednesday
Sep 3rd
Bartch (elbow) was a full participant at the 49ers' practice Wednesday, Cam Inman of The San Jose Mercury News reports.
#2 RDE
Sam Okuayinonu: Logs full practice Wednesday
Sep 3rd
Okuayinonu (shoulder) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#2 DT2
CJ West: Logs full practice Wednesday
Sep 3rd
West (knee) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#1 SCB
Upton Stout: Recovered from calf injury
Sep 3rd
Stout (calf) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#1 LDE
Mykel Williams: Full participant in practice
Sep 3rd
Williams (knee) practiced in full Wednesday, Cam Inman of The San Jose Mercury News reports.
#2 FS
Jason Pinnock: Logs full practice
Sep 3rd
Pinnock (heel) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#1 RCB
Deommodore Lenoir: Recovered from hip injury
Sep 3rd
Lenoir (hip) was not listed on the 49er's injury report Wednesday, Cam Inman of The San Jose Mercury News reports.
#1 RDE
Nick Bosa: Fades injury report
Sep 3rd
Bosa (neck) was not listed on Wednesday's injury report, Cam Inman of The San Jose Mercury News reports.
#2 QB
Mac Jones: Past knee injury
Sep 3rd
Jones (knee) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#3 RB
Isaac Guerendo: Full practice Wednesday
Sep 3rd
Guerendo (shoulder) practiced fully Wednesday, Cam Inman of The San Jose Mercury News reports.
#3 WR
Marquez Valdes-Scantling: Signed to active roster
Sep 2nd
The 49ers signed Valdes-Scantling to the active roster from the practice squad Tuesday, Aaron Wilson of KPRC 2 Houston reports.
#3 RCB
Jakob Robinson: Moves to IR
Aug 27th
Robinson (forearm) was placed on injured reserve Tuesday.
#9 WR
Jacob Cowing: Lands on injured reserve
Aug 27th
The 49ers placed Cowing (hamstring) on injured reserve Wednesday.
#3 LDT
Kevin Givens: Heads to IR
Aug 26th
Givens (pectoral) was placed on injured reserve Tuesday.
#3 FS
Malik Mustapha: Lands on PUP list
Aug 26th
Mustapha (knee) was placed on the reserve/PUP list Tuesday.
#3 QB
Kurtis Rourke: Shifts to NFI list
Aug 26th
Rourke (knee) was placed on the reserve/non-football injury list Tuesday.
#8 WR
Brandon Aiyuk: Shifts to reserve/PUP list
Aug 26th
The 49ers moved Aiyuk (knee) to the reserve/PUP list Tuesday.
HOU
Texans News
#1 RG
Ed Ingram: Not playing Week 1
Sep 7th
Ingram is inactive for Sunday's game against the Rams due to an abdominal injury.
#5 RB
British Brooks: Won't play Week 1
Sep 7th
Brooks (coach's decision) is inactive for Sunday's game against the Rams.
#5 WR
Xavier Hutchinson: Could see added snaps Sunday
Sep 7th
Hutchinson could be a candidate to get starter-level snaps in Sunday's season opener versus the Rams, Ian Rapoport of NFL Network reports.
#1 RB
Nick Chubb: Slated to open season as bell cow
Sep 7th
The Texans envision Chubb serving as their "bell-cow running back" in Sunday's season opener versus the Rams, Ian Rapoport of NFL Network reports.
#1 FB
Jakob Johnson: Elevated from practice squad
Sep 6th
The Texans elevated Johnson from the practice squad Saturday.
#2 RT
Blake Fisher: Ready to roll for season opener
Sep 5th
Fisher does not have an injury designation ahead of Sunday's matchup against the Rams.
#4 WR
Jaylin Noel: Bigger role imminent
Sep 5th
Noel is set for a larger role for the Texans on Sunday versus the Rams due to both Christian Kirk (hamstring) and Braxton Berrios (hamstring) being ruled out for the game, Sam Warren of the Houston Chronicle reports.
#3 WR
Jayden Higgins: More targets on tap
Sep 5th
Higgins is in line for an elevated role in the Texans' passing game Sunday against the Rams after fellow WR Christian Kirk (hamstring) was ruled out for that contest.
#7 WR
Braxton Berrios: Out for Week 1
Sep 5th
Berrios (hamstring) has been ruled out for Sunday's game against the Rams.
#2 WR
Christian Kirk: Ruled out this week
Sep 5th
Kirk (hamstring) has been ruled out for Sunday's season opener versus the Rams.
#2 LT
Cam Robinson: Back to full practice
Sep 4th
Robinson (illness) returned to practice Thursday as a full participant.
#1 FS
C.J. Gardner-Johnson: Healthy ahead of Week 1
Sep 3rd
Gardner-Johnson (knee) did not appear on the Texans' injury report Wednesday.
#1 TE
Dalton Schultz: Restructures contract with Houston
Sep 2nd
The Texans restructured Schultz's contract Tuesday to convert the $11.5 million he was slated to make into a signing bonus, Aaron Wilson of KPRC 2 Houston reports.
#2 QB
Davis Mills: Receives one-year extension
Sep 2nd
Mills and the Texans agreed Tuesday on a one-year, $7 million contract extension, Adam Schefter of ESPN reports.
#3 LDE
Denico Autry: Sidelined to begin season
Aug 27th
Autry (knee) was placed on the reserve/PUP list Tuesday.
#6 RB
Joe Mixon: GM noncommittal on return in 2025
Aug 27th
Texans general manager Nick Caserio declined to answer in the affirmative when asked Wednesday whether Mixon (foot/ankle) will suit up this season, DJ Bien-Aime of ESPN reports.
#2 SCB
Alijah Huzzie: Starting season on NFI list
Aug 27th
Huzzie (undisclosed) was placed on the reserve/non-football injury list Tuesday.
#2 SS
Jaylen Reed: Placed on IR, designated to return
Aug 26th
Reed (ankle) was placed on injured reserve with a designation to return Tuesday.
#4 TE
Irv Smith: Placed on season-ending IR
Aug 26th
The Texans placed Smith (ankle) on injured reserve Tuesday.
#8 WR
Tank Dell: Moved to reserve/PUP list
Aug 26th
The Texans placed Dell (knee) on the reserve/PUP list Tuesday.
#3 FS
Jimmie Ward: Placed on exempt list
Aug 26th
The Texans placed Ward (undisclosed) on the Commissioner Exempt List on Tuesday, Tom Pelissero of NFL Network reports.
#3 RB
Dare Ogunbowale: Projected for 53-man
Aug 25th
Ogunbowale is expected to earn a roster spot in the initial 53-man roster projection compiled by DJ Bien-Aime of ESPN.com.
#1 ROLB
Christian Harris: Suits up Saturday
Aug 24th
Harris recorded two tackles in Saturday's 26-7 preseason win over the Lions.