Jalen Hurts, Ryan Tannehill and Lamar Jackson were all ruled out Thursday, but Nick Chubb is set to play through his foot injury in brutal weather.
With Josh Jacobs and Joe Mixon listed as questionable ahead of late kickoffs, it's unclear if Zamir White and Samaje Perine will be startable in fantasy leagues,
Kyler Murray is one of four starting quarterbacks listed as questionable, while Jonathan Taylor, Aaron Jones, Elijah Mitchell and Kyren Williams all got the green light Friday.
Jaire Alexander might be able to contain Justin Jefferson, but the Packers might not have the luxury of matching them up.
Jerry Donabedian makes the case for Atlanta biding adieu to Matt Ryan, though Falcons owner Arthur Blank may have other ideas.
A matchup with San Francisco's backup corners should be the right trick to get Ja'Marr Chase back on track.
The spotlight is on Michael Gallup as the Dallas offense tries to operate potentially without CeeDee Lamb and Amari Cooper.
Jamison Crowder could be busy running against the interior of Miami's defense, away from Xavien Howard and Byron Jones.
The Chiefs are a formidable opponent, but not because of their run defense. Can the Browns pull off an upset if Nick Chubb has a big game?
Juan Carlos Blanco takes you through all the latest news on key injuries for a highly anticipated Week 1 of what promises to be a unique 2020 NFL season.
No matter whether he runs more from the slot or out wide, it's difficult to see what the Raiders corners can do to slow down D.J. Moore.
Jason Garrett drew ridicule as the head coach of the Cowboys, but his background as a quarterbacks coach could be beneficial for Daniel Jones with the Giants.
With Tampa Bay's top corner questionable with an ankle issue, DeAndre Hopkins is in position to deliver for his owners in Championship Week.
The Steelers found success moving James Washington to the slot in Week 13, and he's poised for another strong game against a limping Arizona cornerback rotation in Week 14.
Jim Coventry analyzes this week's top IDP plays as Aaron Donald and the Rams' D-line could be in for a big day against the Cardinals.
Chris Carson fumbled against Philadelphia in a game where Rashaad Penny went over triple-digit rushing yardage, bringing the former first-round pick back onto the fantasy radar.
The Jets secondary is weak where Tyrell Williams runs his routes, positioning the Raiders wideout to go over 100 yards for the first time since Week 1.
With projected matchups against two rookie corners as Nick Foles returns to the field, it may be time for D.J. Chark to return to the spotlight.