CeeDee Lamb could have one of his biggest games playing against a Lions defense that's tougher against the run than the pass.
If New England prioritizes defending Travis Kelce then the Pats might not have leftover personnel to cover Rashee Rice.
Ja'Marr Chase should keep rolling against a Colts secondary with poor boundary corner personnel.
The Saints are tougher on the boundary than in the slot, which should provoke a big game from Amon-Ra St. Brown.
The Indianapolis secondary is weakest on the boundary and downfield, where Mike Evans is at his best.
The Seahawks' injury report was loaded throughout the week, but Friday brought good news for anyone counting on Kenneth Walker or Tyler Lockett this Sunday.
The Vikings face a simple reality Sunday: either Jordan Addison has a strong game, or the Minnesota passing game falls apart.
It might be now or never for DeAndre Hopkins, who catches the Colts battered and weak at cornerback.
The Dolphins are looking to bring a shootout to the Bills, but Stefon Diggs is prepared to shoot back against Miami's questionable pass defense.
Christian Kirk should maintain momentum against a Houston defense without two of its top three corners, including their slot defender.
After struggling on the road in his NFL debut Bryce Young will look to regather himself in his first home game Monday.
Drake London is due for a bounce-back after no catches in Week 1, but Jaire Alexander could deny it anyway.
The Colts' cornerback personnel is weak but their run defense is strong, setting up a feast for Calvin Ridley and the Jags passing game.
Chris Olave could finish his remarkable rookie season in strong fashion against Carolina's backup corners.
Amon-Ra St. Brown and the Lions receivers project for a substantial advantage against the Chicago secondary.
Mike Williams should climb the ladder against Tennessee CBs that lack reach.
It's been an encouraging breakout season for Christian Kirk, but he draws a buzzsaw assignment against Marlon Humphrey.
Terry McLaurin should stay hot in an indoor game against a Houston defense that lacks speed.