This article is part of our DraftKings MLB series.
Tyler Anderson, COL at PHI ($9,500): Anderson has a chance to exploit the Phillies' ineptitude against southpaws, which is evidenced by a league-worst .281 wOBA and anemic .109 ISO against that handedness. He's enjoyed a solid season all around and has been better on the road, generating a 0.96 WHIP and 3.06 ERA over 17.2 innings away from Coors Field. He's also scored 17.3 to 23 fantasy points over his last four starts, going at least six frames in each. To top it off, Anderson netted 20.1 fantasy points in a quality start against this same squad on July 9.
Adam Conley, MIA vs. CWS ($7,000): Conley checks in at a bargain price relative to his upside, particularly at home and against a White Sox squad that's whiffed at a 22.5 percent rate against southpaws. Conley had a rough outing his last time out, but given the fact it was in Coors Field, it can likely be written off as an outlier. He's also been particularly tough at Marlins Park this season, allowing only two earned runs over the 12.2 innings encompassing his last two starts there, and generating a 2.88 ERA and .227 average against in 59.1 home innings overall.
Sandy Leon, BOS vs. ARI ($3,300): With Leon still checking in at a bargain price and drawing a highly favorable matchup, I'm going right back to the well with the Red Sox backstop. He should be raring to go after a night off Friday and faces D-backs starter Archie Bradley, who's given up a .401 wOBA, 5.02 xFIP and 40.2 percent hard contact rate to lefty hitters. Leon continues to be lethal at Fenway Park, tallying a .438 wOBA and .219 ISO at home, while also racking up a 35 percent hard contact rate there against right-handed pitching.
David Ortiz, BOS vs. ARI ($4,900) Given Bradley's considerable struggles against lefty hitters, Ortiz becomes a natural play as well, particularly at Fenway, where he has a .472 wOBA and .368 ISO, including a jaw-dropping .503 wOBA and astronomical .427 ISO against right-handers there. Throw in his 44.8 percent hard contact rate against righty arms, and Bradley's 21.2 percent HR/FB rate against lefty bats, and you've got a recipe for a potentially explosive return from Big Papi.
DJ LeMahieu, COL at PHI ($3,700): LeMahieu is enjoying a stellar season overall, including a .362 wOBA against right-handed pitching. He's also wielding a red-hot bat in August, having hit safely in seven of his last eight contests, including a 2-for-4 night in the series opener Friday that included a solo homer. While a lot of his success has admittedly come at Coors Field, he's gone 4-for-11 with Friday's homer, two RBI, three walks and three runs over his last three road contests.
Jake Lamb, ARI at BOS ($5,300): Despite Lamb's elevated price, I'm tabbing him for what could be a high-scoring game between the D-backs and Red Sox. Boston starter Clay Buchholz brings a .387 wOBA against lefty bats into Saturday's game, along with a 6.59 xFIP and 34.5 percent hard contact rate when facing them at Fenway. Lamb is just about the last hitter Buchholz will want to see given his .411 wOBA, .320 ISO, 20 homers and massive 44.9 percent hard contact rate against right-handed pitching this season.
Manny Machado, BAL at SF ($4,100): Machado is a contrarian play given his matchup against Madison Bumgarner, but the Giants ace has actually proven vulnerable to righty hitters, giving up 15 of his 18 homers on the season to that handedness. Machado also has a .387 wOBA and 37.4 percent hard contact rate, as well as double-digit fantasy points in five of his last eight games.
Giancarlo Stanton, MIA vs. CWS ($4,300): James Shields takes the mound for the White Sox, making Stanton a tournament play with monumental upside. Shields was absolutely blasted by the Orioles in his last start, allowing eight earned runs and four homers in just 1.1 innings, and he has a .377 wOBA and 5.15 xFIP against righty bats. He's also yielded hard contact to right-handed hitters at a 38.6 percent clip, while Stanton has a .332 wOBA, .231 ISO and 17 of his 24 homers against righty arms, and a 44.4 percent hard contact rate and 22.2 HR/FB rate at Marlins Park.
Jackie Bradley, Jr., BOS vs. ARI ($4,300): Bradley is our third left-handed bat against Archie Bradley, whose vulnerability to those hitters has already been detailed. Bradley takes full advantage of Fenway's dimensions as well, posting a .404 wOBA, .228 ISO and 34.2 percent hard contact rate at home. He's also punished right-handed pitching there, with a .317 batting average, .398 wOBA, .232 ISO and seven homers.
Michael Saunders, TOR vs. HOU ($3,600): Saunders is always in play at this price, considering the upside he brings. He's tailed off some since earlier in the season but still brings the potential for double-digit fantasy production in any given game, especially at Rogers Centre. He's tallied a .387 wOBA, .221 ISO and 40.7 percent hard contact rate against right-handed pitching at home, while Astros starter Colin McHugh has yielded a .369 wOBA and 35.2 percent hard contact rate to left-handed hitters away from Minute Maid Park.