This article is part of our Showdown/Single Game DFS Breakdown series.
Aside from a Week 1 stumble against Pittsburgh, the Buffalo Bills have generally displayed the form that made them so dangerous in 2020. After a slow start to the year Josh Allen has turned in recent weeks back into his prior form, and with an improved defense at his side the Bills appear potentially even more dangerous than they were as already-playoff contenders in 2020. One of the few rough points in their 2020 season was their Week 5 matchup with the Titans in Tennessee, a game where the Bills were 4-0 and seemingly unstoppable before losing in a somewhat shocking 42-16 dud effort.
Now the Bills head back to Tennessee, in the same place and nearly the same time as last year's meeting, but the scenario is much different on the Titans' side. Both teams were undefeated in last year's showdown, whereas this year the Titans are already reeling and their playoff ambitions in peril after an ugly 3-2 start. Injuries to star wideouts A.J. Brown and Julio Jones have paired with offensive line struggles to reduce the Titans basically to the Herculean efforts of Derrick Henry – good enough to win three out of five maybe, but probably not four out of six if the sixth team is one like this Bills squad. Still, the Titans almost certainly feel an urgency they didn't in the 2020 game. We'll see if that urgency is enough to overrule the sharp focus the Bills have shown to this point.