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Best Bets for LSU Tigers vs. Vanderbilt Commodores | Vanderbilt Commodores -2.5 (-110)
One of the big matchups in the SEC today features No. 12 LSU on the road against No. 17 Vanderbilt. These opponents have logged wins in very different ways, with the Tigers leaning on their top-five scoring defense, while the Commodores field the nation's seventh-ranked scoring offense.
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Vanderbilt QB Diego Pavia will look to bounce back from the team's first loss of the season in Week 6 against Alabama. The Commodores' offense will have to overcome LSU's stout defense, which has only allowed more than 10 points once in six games.
Oddsmakers on bet365 are laying -2.5 with Vanderbilt as a home favorite, along with a 48.0 point total. LSU's offense has struggled mightily in 2025, ranked 87th in the nation in points per game.
LSU QB Garrett Nussmeier has yet to replicate his production from 2024. Now, he's going on the road and will have to keep up with Pavia and the Commodores' top-10 offense.
Let's bet on Vanderbilt to cover -2.5 as a field-goal favorite at home. The Commodores have a rest advantage following a Week 7 bye, plus their defense is a top-40 unit, meaning LSU will struggle to keep pace with Vanderbilt's high-octane offense.
Best Bets for LSU Tigers vs. Vanderbilt Commodores | Over 48.0 (-110)
LSU's defense has only faced one quality offense, which came during their lone loss against Ole Miss. Otherwise, their ability to shut down opponents hasn't been overly impressive, playing struggling offenses like Clemson, Florida, and South Carolina.
Vanderbilt has also had a fairly easy schedule, excluding a double-digit loss to Alabama. However, the Commodores have logged at least 333 yards of offense in every game, including a 6.6 YPC average and 34 total touchdowns.
Let's bet over 48.0 total points in this SEC tilt. Pavia and Vanderbilt's offense will come out of their bye week humming, while Nussmeier and LSU's offense will exploit the Commodores' secondary enough to score at least 20 points.
Best Bets for LSU Tigers vs. Vanderbilt Commodores | Vanderbilt Commodores Moneyline (-135)
We've already locked in Vanderbilt -2.5 on the point spread at -110 odds. Let's double down and lay a bit more juice on the Commodores' moneyline at -135.
LSU's defense hasn't faced an offense as dynamic and explosive as Vanderbilt's this season. The Tigers rely on turnovers to keep their struggling offense ahead of schedule. However, the Commodores have only committed six total turnovers on offense in 2025.
Factor in home field and bye week rest as advantages that favor Vanderbilt in this matchup. Until LSU proves it can score more than 23 points against an FBS opponent, we have to fade them.
LSU Tigers vs. Vanderbilt Commodores Picks
- Vanderbilt Commodores -2.5 (-110)
- Over 48.0 (-110)
- Vanderbilt Commodores Moneyline (-135)
Best Events to Use the bet365 Bonus Code: ROTOWIRE For on October 18th
- College Football: Ole Miss Rebels vs. Georgia Bulldogs. A top-10 matchup in the SEC with oddsmakers laying -7.5 with the Bulldogs and a 54.5 point total.
- College Football: Texas Tech Red Raiders vs. Arizona State Sun Devils. The undefeated Red Raiders are laying -7.5 as road favorites against Sam Leavitt and the Sun Devils with a 52.5 point total.
- MLB: Milwaukee Brewers vs. Los Angeles Dodgers - NLCS Game 5 (if necessary) at Dodger Stadium at 8 p.m. ET.
- NHL: Seattle Kraken vs. Toronto Maple Leafs. Jared McCann and the Kraken hit the road for a matchup against the Maple Leafs at 7 p.m. ET on NHL Network.
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