This article is part of our Sweet 16 Preview series.
Site: Indianapolis, IN
Tip-off: Sunday, 2:10 p.m.
In the West Region highlighted by undefeated Gonzaga, each of the other three favorites in the quadrant suffered upset losses during the first two rounds of the NCAA Tournament. No. 4 Virginia was unable to practice during much of the week leading up to the tournament, and Ohio was able to pull off an upset. No. 3 Kansas also dealt with COVID-19 issues of its own during the Big 12 Tournament but advanced to the second round of the NCAA Tournament with a nine-point victory. However, the Mobley brothers took charge for USC during the second round and led the Trojans to their first Sweet 16 since 2007. No. 2 Iowa was in control for most of the team's first-round matchup against Grand Canyon, but the Hawkeyes struggled against the experienced Oregon program in the second round and suffered a 90-75 loss.
Top-seeded Gonzaga had little trouble during a 43-point victory over Norfolk State in the first round of The Big Dance. The Zags shot 49.1 percent from the floor during a closer matchup against Oklahoma in the second round, but the team was dominant on the offensive boards and pulled off an 87-71 win over the Sooners. No. 5 Creighton struggled mightily during the Big East Tournament final and nearly suffered an upset loss during the first round of the NCAA Tournament. The Bluejays faced Cal-Santa Barbara to begin the tournament, and the Gauchos