We have 12 games on tap for Week 2's main slate on DraftKings, and we'll be reaching deep into this pool for wideout talent to offset our spend-ups at quarterback and running back. Let's begin with the Vegas odds and other pertinent stats about the available teams.
College Football DFS DraftKings Saturday Main Slate Overview for Week 2

We have four games laying massive point totals to underdogs this week, so we'll need to carefully select first-string starters for the favorites. Often, two quarters of production from a first-string offense is more than enough to carry the day, but limiting your exposure to these scenarios is usually a safe bet. High projected totals matched with a narrow point spread are usually high-value DFS targets, and the Baylor-SMU matchup is our best example on this slate.
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FIU-Penn State: 76 percent chance of rain
Saturday DraftKings Main slate College Football DFS Picks for Week 2
Quarterback
Sawyer Robertson, Baylor ($7,700) @ SMU
The Bears committed too many mistakes and took a Week 1 loss despite a massive performance from Robertson. His line wasn't without blemishes, as he only managed to connect on 56.3 percent of his passes, and the run game was almost non-existent, which didn't help matters for the passing offense. Although I also like SMU's Kevin Jennings ($8,000) in this spot, I give a slight edge to Robertson due to his impressive history of prolific games over the past year. I won't fault anyone for taking Jennings, however.
Arch Manning, Texas ($9,600) vs. San Jose State
The loss to Ohio State should allow Manning's expectations to decrease from the hype-filled heights in the preseason, and it's reasonable to assume the team wants Manning to get comfortable against a weak opponent. Despite the massive spread, this game will give Manning some much-needed confidence after being picked apart by the Buckeyes. For that reason, I think we'll see a little more from Manning beyond halftime, and I'll take the elevated salary if my other expenditures allow for it.
Also consider: Austin Simmons, Mississippi ($7,300) @ Kentucky
Running Back
Bryson Washington, Baylor ($8,900) @ SMU
I will stick with this shootout and assume that the Bears will do some serious retooling to get Washington back on track. His Week 1 result was completely uncharacteristic of his potential as an elite runner. SMU's run defense isn't bad, but Washington proved that he can find holes against excellent defenses last season, and I am chalking up his Week 1 performance as an outlier.
Hollywood Smothers, North Carolina State ($6,500) vs. Virginia
Smothers had some competition from the bench last week, but he's still the clear leader in the backfield. Virginia did a number on Coastal Carolina, but the Chanticleers are a shadow of their former selves, and I don't see the Cavaliers' blowout as a notable achievement. The Wolfpack had trouble putting away East Carolina, and while I'm not confident in the team as a whole, there's no question that Smothers will be an integral part of the offense as a risher and pass-catcher. His salary is also alluring and much lower than other notable names on the slate.
Kewan Lacy, Mississippi ($5,300) @ Kentucky
Lacy is an excellent cost-saving opportunity at running back. Coach Lane Kiffin likes to run up the score, so I expect Lacy to still be highly utilized even if the game gets out of hand. He finished with one of the best results among FBS running backs in Week 1, and I expect his usage to remain high.
Wide Receiver
We've spent a lot of our salary allotment above, but I've targeted a few low-cost, high-upside pass catchers who can keep us solvent.
Emmanuel Henderson, Kansas ($5,300) @ Missouri
Eagle-eyed players will notice that there's some sort of stat snafu (as of this writing) where DraftKings isn't including last week's game against Wagner in the game logs. Whether this is related to Henderson's low salary is an open question, but we'll take advantage of this salary point from one of Jalon Daniels' favorite targets. The stat omission is also true for Cam Pickett's ($5,000) game logs. I'm fine with either player, as both are projected to play a major role against a tough opponent.
Cooper Barkate, Duke ($4,900) vs. Illinois
The jury is still out regarding the Blue Devils, but this weekend's game against Illinois will be a good indication of how they hold up against stiffer competition. Darian Mensah was cool and composed under center in Week 1, and Barkate led the receiver room with five receptions off of eight targets. Although he didn't score, the Harvard Transfer surpassed the century mark in the blowout win against Elon. Things won't be nearly as easy against the Illini, but his target volume is certainly encouraging.
Harrison Wallace, Mississippi ($4,900) @ Kentucky
Ole Miss has a deep WR room led by Cayden Lee and De'Zhaun Stribling, but Wallace ended Week 1 as Austin Simmons' top option. Lee or Stribling could bounce back and outpace Wallace this week, but Wallace's eight targets may be a good indication that he'll be heavily involved. It could be a matter of absorbing the playbook better than the other transfers after four seasons with Penn State, but the synergy between Wallace and Simmons was evident in Week 1.
Also consider: Romello Brinson, SMU ($4,800) vs. Baylor, Kole Wilson,
Baylor ($4,600) vs. SMU