The 49ers generally like to run the ball, but with Raheem Mostert out and facing one of the worst pass defenses in the league, RotoWire's Andrew Laird is expecting a big game from George Kittle.
The Bengals will be without starting running back Joe Mixon on Sunday against the Browns, and RotoWire's Andrew Laird is expecting Joe Burrow to pick up some of the rushing slack.
Kenny Golladay has a touchdown in each of his last two games, and RotoWire's Andrew Laird sees a few Lions bets that could take advantage of their favorable passing matchup against the Jaguars.
The Jaguars continue to rely heavily on running back James Robinson, who RotoWire's Andrew Laird is expecting to make a big impact Sunday against the Texans.
The Buccaneers will be without Chris Godwin on Sunday against the Chargers, and RotoWire's Andrew Laird sees an opportunity to take advantage of a Mike Evans receiving yards prop.
Austin Ekeler continues to lose rushing attempts to Joshua Kelley, but RotoWire's Andrew Laird sees an Ekeler player prop on FanDuel Sportsbook that should be strongly considered.
The Buccaneers are 8.5-point home favorites against the Panthers in Week 2, and Ronald Jones could help bettors who like Tampa Bay but may not want to rely on them covering the spread or just bet the moneyline.
The NFL is back and so is betting on the league, with RotoWire's Andrew Laird using some of the site's content and tools to help him choose entertaining bets for Week 1.
The Saints are big favorites in their regular-season finale against the Panthers, and RotoWire's Andrew Laird sees some ways to take advantage with Alvin Kamara.
No team has allowed more rushing yards than the Dolphins, who will now have to try and contain Joe Mixon after he racked up 282 yards in the past two games.
Chris Godwin is expected to be a fantasy star in Week 15, and sports betters can take advantage of that on FanDuel Sportsbook this weekend.
Devonta Freeman has an excellent matchup against the Panthers' poor run defense Sunday, but will the Falcons do enough to actually win the game?
Davante Adams seems to be Aaron Rodgers' only trusted receiver, and RotoWire's Andrew Laird thinks they'll connect early and often Sunday against the Giants.
The Titans are a popular pick among RotoWire staffers this week, and RotoWire's Andrew Laird explains how bettors can take advantage with help from Derrick Henry.
The Cowboys are favored by a touchdown against the Lions on Sunday, and RotoWire's Andrew Laird is expecting Ezekiel Elliott to be heavily used in a Dallas win.
The Colts are heavily favored against the Dolphins on Sunday, and RotoWire's Andrew Laird think Marlon Mack is going to play a big role in their win.
The Buccaneers have been excellent against the run this season, and RotoWire's Andrew Laird is expecting Russell Wilson to air it out Sunday in Seattle.
Saquon Barkley is ready to break out against the Lions on Sunday, and RotoWire's Andrew Laird sees a nice payoff for those willing to bet on a big game from the Giants' star running back.
The Cowboys vs. Eagles game is sitting with a 49.5-point total (-110/-110) on FanDuel Sportsbook, but RotoWire's Andrew Laird has a way to get the same payout while only needing 40 points to hit.
The Ravens are heavily favored at home against the Bengals on Sunday, and RotoWire's Adam Zdroik has a few creative ways to benefit from a big Baltimore win.
The Chargers are favored at home against the Broncos on Sunday, and RotoWire's Andrew Laird think Austin Ekeler will help get them there.
The Colts are favored at home against the Raiders on Sunday, and RotoWire's Andrew Laird thinks betting on Marlon Mack could be profitable.
The Cowboys are heavily favored at home against Miami on Sunday, and RotoWire's Andrew Laird has a few creative ways to bet on Dallas without dealing with the spread or total.
Sony Michel struggled in Week 1's dominant win over the Steelers, but he has a great opportunity to bounce back Sunday against the Dolphins, as the Patriots come in as 18.5-point favorites in Miami.
The Cardinals' offense is the big unknown in Week 1, but there are a few bets worth considering if you're a believer in Kyler Murray being able to quickly handle Kliff Kingsbury's high-tempo offense.