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This Week 2 slate will begin to give us a little more clarity going forward, and the 1:00 window has some intriguing matchups like the Jacksonville Jaguars at Cincinnati Bengals, the Chicago Bears at Detroit Lions, and the Buffalo Bills at New York Jets in an AFC East showdown. The 4:00 is a bit trimmed down this week, but the main event resides there, with the Eagles-Chiefs game. Both teams got a little extra rest, but you have to wonder if that unsuccessful trip to Brazil will be a little too much for KC to overcome in this revenge game.
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Best Bets for NFL Sunday Week 2 Games
Best Bets for Jaguars at Bengals | Jaguars +3.5
I don't mind taking a shot on underdogs early in the season to maximize the most potential value. Everyone loves the Bengals this season, but they have an atrocious defense that wasn't fully unmasked in Week 1. The Jaguars have a new look under new head coach Liam Coen and got an easy win in the opener.
Granted, it won't be that easy this time around, but I like the chances here. This spread has dropped from +5.5 to +3.5 (ML from +195 to +155), and while the percentage of bets are close to 50-50, nearly 85% of the money is coming in on the Jags to cover.
Best Bets for Carolina Panthers at Arizona Cardinals | Cardinals -6.5
Granted, there was an in-game delay, but it was not a pretty season opener for the Panthers. Bryce Young was wildly inaccurate, going 18-for-35 with two picks and a fumble lost. The Cardinals have been one of the most hyped teams coming into the season, and they turned in a so-so performance down in New Orleans last week.
But now, this is their chance to really show what they're made of. Look for the Cardinals to have a balanced attack in handling the Panthers rather easily. As for the bets-to-money ratio, Carolina is getting 60% of the bets while 60% of the money is landing with Arizona.
Best Bets for Eagles at Chiefs | Eagles -1.5
The Chiefs struggled quite a bit after losing Xavier Worthy early in last week's loss, and that can certainly continue against the Eagles. I'll be honest, I'm outrageously shocked that the spread is even this close, despite the Chiefs having homefield advantage.
Philly's secondary was shredded by Dak Prescott in the opener, but KC still has plenty of question marks at the skill-playing positions. Simply put, I believe the Eagles are the better team here and they'll win this one easily. KC is getting about 65% of the bets while Philly is taking in 80% of the money.
NFL Sunday Week 2 Picks
- Jaguars +3.5
- Cardinals -6.5
- Eagles -1.5
Best Events to Use the BetMGM Bonus Code for Sunday, September 14, 2025
- NFL: Chicago Bears at Detroit Lions, 1 p.m. ET | Both teams got off to a sluggish start in Week 1, and neither one wants to drop to 0-2 in what will appear to be a very competitive NFC North.
- NFL: Buffalo Bills at New York Jets, 1 p.m. ET | The Bills are coming off a miraculous win last, but can they keep that momentum going against a Jets team looking to get their first win?
- NFL: Philadelphia Eagles at Kansas City Chiefs, 4:25 p.m. ET | Well, it didn't take long to get a Super Bowl rematch, and the Chiefs will have the Arrowhead home crowd on their side for this one.
- MLB: Los Angeles Dodgers at San Francisco Giants, 4:05 p.m. ET | The Dodgers look to inch closer towards an NL West title with a win against their bay-dwelling rivals.
- MLB: New York Yankees at Boston Red Sox, 7 p.m. ET | Speaking of rivalries, we're getting the best of them all on ESPN's Sunday Night Baseball. The Red Sox throw their ace, Garrett Crochet, and up against the youngster, Will Warren.
- WNBA: Indiana Fever at Atlanta Dream, 3 p.m. ET | The WNBA Playoffs tip off today, and everyone will be tuned in to see how the Fever can go without Caitlin Clark in the lineup.
