This article is part of our FantasyDraft MLB series.
Antonio Senzatela, COL at SD ($12,400): Senzatela has toed the rubber five times this season with only one bad start on his resume. Considering he's a starter for the Rockies, that's saying quite a bit. The fact that his lone poor start came at the hands of the Nationals, in Colorado, is not lost on me either. Senzatela gets a great matchup against the Padres, who have the worst K% against righties this season. Their wOBA against righties is below .300 as well, so there's really no reason to avoid him. He's also priced among the dregs of the league, yet is one of the better plays on the slate.
Gio Gonzalez, WAS vs. AZ ($17,200): The D-Backs are a completely different animal at home than they are on the road. In this case, their overall numbers against lefties are pretty good, but when breaking them down by home/road, a different story emerges. The Diamondbacks have the worst wOBA against lefties on the road this season and they are seventh worst in K%. Gonzalez is off to a nice start this season with a 1.62 ERA through five starts and 26 strikeouts in 33 1/3 innings. This looks like a great spot to improve his K% and likely pick up a win.
Josh Harrison, PIT at CIN ($7,600): Harrison has been on a roll lately with three home runs in his past two games. Although we can't guarantee another homer, his odds of producing are pretty high again against Rookie Davis. Davis is in a similar spot as Tyler Glasnow was on Tuesday — pitching for his major-league life. Davis managed to get through his first few starts without blowing up, but that all changed in his most recent start against Milwaukee when he gave up seven runs on 11 hits. While we can't expect another outing like that, it's reasonable to predict a lot of production from the entire Pirates lineup.
Josh Bell, PIT at CIN ($6,600): With Davis on the hill for the Reds, you'll want to have at least two Pirates in your lineup. Bell is a guy who might not be a popular pick just yet, but his matchup here looks very promising. While Davis has been kind to righties this season, he's been down right generous to lefties. Bell gets most of his points from the long ball, but considering Davis' home run rate to lefties this season is 4.50, there's a decent chance that Bell will take him deep. Bell is among the leaders on the Pirates in wOBA against lefties this season at .375, as well.
Mike Moustakas, KC vs. CHW ($7,200): With Mike Pelfry on the mound for the White Sox, I had to mention at least one Royal. With that said, the way the Royals are hitting this season, one Royal is about all you want on any given slate. Moustakas leads the Royals in wOBA against righties this season at .400 and it's never a bad idea to target a lefty against Pelfry.
Avisail Garcia, CHW at KC ($7,200): The Royals aren't the only team in this game with a favorable matchup as the White Sox get to face Nate Karns, who after a couple solid starts, has fallen apart in his last two outings. Karns has surrendered 10 runs in just over 10 innings in those two starts. Garcia is off to a tremendous start this season with five home runs, 15 RBI and 20 runs through 23 games. Garcia also leads the team in wOBA against righties this season at .411, so it makes sense to target him against Karns.
Corey Dickerson, TB vs. MIA ($6,800): Dickerson is one of a few lefties in the league that I don't mind targeting against southpaws. Dickerson is ranked ninth in baseball in wOBA against lefties this season with a .504 mark. He'll face Adam Conley, who — in his most recent game — failed to make it out of the second inning. Dickerson is a safe play with high upside, even against lefties.
Mookie Betts, BOS vs. BAL ($10,000): Betts' price is still reflective of his production last season despite struggling out of the gate this year, but he gets a nice matchup against Kevin Gausman on Wednesday. In Gausman's last three starts, he's surrendered 18 runs and 24 hits and is walking multiple batters in every outing.
Manny Machado, BAL at BOS ($9,600): All the drama of the slide on Dustin Pedroia and the resulting retaliation seems to have lit a fire under Machado, who didn't start the season so well, but is now on a tear. Machado has homered in three of his past five games and is averaging over 16 fantasy points per game in his last five. He faces lefty Drew Pomeranz, who has already given up five long balls in just over 21 innings this season, four of which have gone to righties.
Miguel Sano, MIN vs. OAK ($8,000): Sano is on fire right now. Over his past five games, Sano has four home runs, 11 hits and 13 RBI. Sano will face Kendall Graveman, who is pitching pretty well this season, but Sano has hammered righties to the tune of a .479 wOBA, which is good for seventh in all of baseball.