MLB Betting Picks for Sunday, September 28
The last day of the 2025 MLB regular season is finally here. We'll focus our three best bets on games that have direct playoff implications: two in the American League and one in the National League.
Cash in on the best sportsbook promos available at the best MLB betting sites this baseball season. The BetMGM bonus code gets new players one of the best welcome bonuses in the industry.
Best MLB Bets Today
Cincinnati Reds 
vs. Milwaukee Brewers 
: Reds +1.5 run line, -155 @ ESPNBet
The Reds are going neck-and-neck with the Mets as the final NL Wild Card spot is still up for grabs on the final day of the season. The Reds hold the tiebreaker over the Mets, meaning a win here sends them to the playoffs, and a loss would force them to see what will happen in Miami between the Mets and the Marlins.
This means the Reds will have motivation to get a good result in this series finale against a Brewers team that already locked up the No. 1 seed in the National League, as well as home-field advantage throughout the World Series. In short, Cincinnati has everything to play for Sunday, whereas the Brewers have nothing on the table. Back the Reds to cover the run line here, as the difference in motivation will tip the scales here in Cincinnati's favor -- even if they don't secure the win against a superior Milwaukee team.
Check out Caesars Sportsbook this MLB season and use the Caesars Sportsbook promo code for one of the top MLB betting promos.
Baltimore Orioles 
vs. New York Yankees 
: Yankees -1.5 run line, +104 @ DraftKings
The Yankees already locked up a postseason berth, but they'll have everything to play for in the final day of the regular season since the AL East title, as well as home-field advantage all the way to the ALCS, is still up for grabs. The Yankees face an Orioles team that has nothing to play for, and the Yankees can't leave anything on the table since they'll also be looking at what happens in Toronto between the Blue Jays and the Rays.
The Yankees already covered the -1.5 run line Saturday following a 6-1 victory and have done so in each of their last four wins. With the offense clicking and the team on a hot streak, expect the Bronx Bombers to close out the regular season with another comfortable victory in hopes of clinching the AL East title.
Check out Fanatics Sportsbook to bet on MLB odds and use the Fanatics Sportsbook promo for a great welcome offer.
Tampa Bay Rays 
vs. Toronto Blue Jays 
: Kevin Gausman 6+ strikeouts, -135 @ bet365
The Blue Jays are tied in first place of the AL East with the Yankees with a 93-68 record, but since Toronto has the edge in the tie-breaking rules, all they need is a win to secure not only the AL East title, but also the home-field advantage throughout the ALCS. Toronto will trust Gausman on the mound as he has pitched at a very high level of late.
Gausman took the loss in his last start, a Sep. 22 matchup against the Red Sox, but he's been solid of late with a 2.37 ERA, 0.89 WHIP and 57:11 K:BB over 60.2 innings in his previous nine starts. The 8.5 K/9 in that stretch is a bit low, but Gausman has fanned at least six in three straight games, and in all but one of his last six starts. That gives him a good floor against a Tampa Bay lineup that ranks 10th in more strikeouts in the majors over the last 30 days.
Check out on one of the top sports betting apps when you sign up with the bet365 bonus code for your baseball betting.
MLB Picks Recap
- Reds vs. Brewers: Reds +1.5 run line, -155 @ ESPNBet
- Orioles vs. Yankees: Yankees -1.5 run line, +104 @ DraftKings
- Rays vs. Blue Jays: Kevin Gausman 6+ strikeouts, -135 @ bet365
