CFB FanDuel DFS Breakdown for Saturday Main Slate
Shootout Potential (games featuring high implied totals on both sides)
Virginia (27.5 implied total) at Louisville (34.0 implied total) - 61.5 game total
Iowa State (27.5) at Cincinnati (29.0) - 56.5 game total
These are the only games with totals above 55 this week, featuring close expected contests, which creates the opportunity for a shootout and stacking of the game on both sides. Scoring in the college game is typically more widespread than it is at the NFL level, so stacking a full game isn't always the right strategy, but it doesn't hurt to do so if a game like Virginia and Louisville turns into a shootout or requires overtime to decide things.
Blowout Potential (more than two TD spread)
Penn State (-24.5, 37 implied total) at UCLA (12.5)
Ohio State (-23.5, 33.0 implied) vs. Minnesota (9.5)
Notre Dame (-20.5, 41.5 implied) vs. Boise State (21.0)
Georgia (-20.5, 34.5 implied) vs. Kentucky (14.0)
Michigan (-17.5, 30.5 implied) vs. Wisconsin (13.0)
Texas A&M (-15.5, 36.0 implied) vs. Mississippi State (20.5)
These contests could result in empty benches at some point in the second half, especially as we move closer to the top of the list in terms of spreads. They also figure to potentially feature additional ground game if teams like Penn State, Ohio State, Notre Dame and Georgia get ahead comfortably in the contests as expected.
Other Noteworthy Implied Totals
TCU (36.0)
Texas Tech (31.5)
Clemson (30.5)
A few more notable totals here for teams to potentially target. Neither blowouts nor high expected totals from opponents here for a shootout, so this is another good spot to potentially target RBs if there are any of note. Competitive contests with high implied totals for these teams.
College Football DFS Weather (winds 15+ MPH, precip. chance 50-plus percent and hot/cold temps noted)
Texas at Florida - Significant chance of rain throughout and winds 16-18 MPH
Notable College Football Injuries/Absences for Week 6
Key players in bold
QB
Tommy Castellanos, Florida State 
- Listed as probable, think he'll be a go
Billy Edwards, Wisconsin 
- Wasn't getting the majority of practice reps early in the week
Zach Calzada, Kentucky 
- Probable this week, still the backup if he's available
RB
Quintrevion Wisner, Texas 
- Listed probable to make his return Saturday
CJ Baxter, Texas - Listed doubtful to suit up Saturday
Isaac Brown, Louisville 
- Considered probable, if not better, for Saturday
Duke Watson, Louisville - Also considered probable or better to play
Keyjuan Brown, Louisville - Listed as questionable to suit up after missing last week
Jamarice Wilder, Louisville - Also considered questionable
Noah Vaughn, Virginia 
- Won't suit up this week
Darius Taylor, Minnesota 
- Hasn't played since Week 2, not holding my breath but look for the pregame availability report Saturday
A.J. Turner, Minnesota - Out for the season
Dilin Jones, Wisconsin - Deemed questionable to play earlier in the week
Caleb Hood, North Carolina 
- Listed probable for this week
Jay Haynes, Clemson 
- Remains sidelined
Jambres Dubar, Boise State 
- Has been sidelined for a couple of weeks and status unclear
Ja'Kobi Jackson, Florida 
- Won't play against Texas
Treyaun Webb, Florida - Still sidelined
Kevorian Barnes, TCU 
- Listed questionable for Saturday, better chance than McAlister from what I've seen
Roydell Williams, Florida State - Listed probable for Saturday
WR
Chris Culliver, North Carolina - Listed probable this week
Jaden Greathouse, Notre Dame 
- Won't suit up this week
Emmett Mosley, Texas - Likely to make Longhorns debut Saturday
Eric McAlister, TCU - Deemed questionable for Saturday, but it sounds he may be leaning doubtful
Jayvan Boggs, Florida State - Listed probable after missing last week
TE
Hogan Hansen, Michigan 
- Hopeful to play, spotted at practice earlier in the week
Tucker Ashcraft, Wisconsin - Hasn't played yet this season, status unclear
Eli Wood, Virginia - Listed questionable for Saturday
Terrance Carter, Texas Tech 
- Listed as probable against Houston
College Football DFS Tools
- FanDuel Lineup Optimizer
- Matchups Page (Vegas odds, opponent averages, etc.)
- Advanced Lineups Page
- Stats
- Team Trends
- Targets
- Defense vs. Position
- Team Rankings
Week 6 CFB DFS Plays on FanDuel
Quarterback
Chandler Morris, Virginia ($12,000) at Louisville
Being the top quarterback on the board likely means Morris will see his fair share of rosters this week, but the juice seems worth the squeeze in this instance. Louisville's per-game stats against opposing QBs don't scream pick against me, but three of its four opponents have been Eastern Kentucky, James Madison and Bowling Green, and last week the Cards faced a Pitt offense sans Desmond Reid. So, color me skeptical that the success thus far will hold. Morris is a dual-threat option under center and has amassed four rushing scores in the past two games. The cards have allowed 179 rushing yards and two scores to opposing QBs on the ground, so this is another spot I could see Morris punching in one or two to boost his output.
Josh Hoover, TCU ($10,300) vs. Colorado
All but one quarterback room (Delaware) that has faced the Buffs this year has scored over average, and Hoover's average, to date, is 23.3 FD points per game. On top of that, the Buffs have been stout against opposing running backs, yielding below-average results to opposing backs. Barnes (as mentioned above) is also nicked up for the Horned Frogs, and he'll likely be operating at less than 100 percent if he plays. While Hoover could be down McAlister for this one as well, the passing attack has plenty of depth, and I'd still roll the dice here.
Drew Allar, Penn State 
($8,800) at UCLA
Allar hasn't posted any big showings to date, and UCLA is allowing a slate-worst 32.7 FD points per game, so all signs point to the running back room here. Now, I'm not saying we shouldn't also consider Nicholas Singleton and Kaytron Allen, but I just feel like this is a spot Allar is going to be overlooked because of the two factors I mentioned. Through four games, Allar hasn't topped 16.7 FanDuel points, so there seemingly isn't a ton of reason to get excited about him. That said, he has yet to find paydirt as a rusher this year, something he did six different times last season and four times the year before. Allar topped 20 FD points in half (six) of the regular season games last season and surpassed 19 in eight of 12, so he's overdue to have that breakout game in 2025. I think this could be it, coming off a tough home loss to Oregon with something to prove.
Running Back
The Top Dogs
Jeremiyah Love, Notre Dame ($12,600) and Jadarian Price ($9,100), Notre Dame vs. Boise State
Both Notre Dame running backs should be in play this week, squaring off against a Boise State defensive front that grades out as one of the worst on the slate. USF's running backs accumulated 74 yards and a score on just 13 carries in the opener, and Air Force and App State's running backs combined for 47.9 fantasy points over the last two weeks.
The Fighting Irish has an argument for one of the best running back duos in the country in the backfield, and this pair should feast against that front in a game the Irish are favored by nearly three touchdowns. Notre Dame needs to win out and do it impressively to remain in the CFP conversation with two losses already on its resume.
Le'Veon Moss, Texas A&M 
($10,200) vs. Mississippi State
Moss has been banged up at points this year, but he displays week in and week out that he's the best back in this Aggies backfield, amassing 139 rushing yards and a score on 21 carries last week against Auburn. The Bulldogs have proven to be stingy thus far in the secondary and have graded out well there, so I wouldn't be shocked if Moss and the backfield is heavily involved in the plan of attack, especially if they get out to a comfortable lead.
Also consider: Penn State RBs (Nicholas Singleton and Kaytron Allen) vs. UCLA - didn't include because I recommended Allar and these two seem destined for heavy RB usage
Mid-Tier Targets
Jam Miller, Alabama 
($8,900) vs. Vanderbilt
Vanderbilt has earned its way to a 5-0 start to the season, but I have my questions in terms of opposition to date. The Commodores have two wins to date against power conference foes, sure. But, those foes are a Virginia Tech team that has since fired its head coach after a 0-3 start and South Carolina, which has taken it on the chin twice already in conference play and also struggled to beat said Virginia Tech squad.
Miller is the undisputed top back in this Bama backfield, and while Alabama's results on the ground don't jump off the page, even Miller in his return from injury last week, the Crimson Tide have also faced three top-20 run defenses in their first four games, per PFF.
Vandy is no slouch on that front, but it grades out 38th compared to 21st in coverage and 16th in pass rush. I get the feeling this is the week we see the Bama ground game unleashed a bit more.
Tawee Walker, Cincinnati 
($7,800) vs. Iowa State
So, the eye test here doesn't indicate the Cyclones are a bad run defense. In fact, they've allowed the second fewest fantasy points per game (8.0) to opposing backs this year. Well, PFF disagrees, grading the unit out as the worst rush defenses on the slate (38th worst). I don't necessarily live by PFF grades, but something isn't adding up here. Part of what has benefited this unit is that they have to allow rushing touchdowns, and that's undoubtedly due to change at some point.
Walker has seemingly taken command of the top spot on the running back depth chart, rushing a season-high 18 times last week versus Kansas, so I'll take a shot here in GPPs and bank on low ownership to potentially provide me with some value. The Bearcats sport a respectable 28.5 implied score, so it's not a terrible spot to take a shot.
Isaac Brown, Louisville ($7,600) vs. Virginia
Brown was a first-round pick in season-long fantasy this season for a reason, and while his numbers against Pitt last week don't really earn him first-round status, that run defense also grades out as a top-10 unit in the country. I'm not going to take that as gospel, and Virginia has held opposing running back rooms from Florida State and Stanford under average the past couple of weeks.
Still, I find myself gravitating toward Brown's talent at this price tag for a Louisville squad sporting an implied 33.5 score and favored by a touchdown. Always bet on the talent.
Bargain Options
Bo Jackson, Ohio State 
($6,900) vs. Minnesota
While Jackson is technically third on Ohio State's depth chart behind CJ Donaldson and James Peoples, his usage last week tells me a different story. Jackson led the way with 17 carries against Washington, while Donaldson (nine) and Peoples (three) combined for only 12.
Jackson looks to be budding into the star of this room and faces a Minnesota front that yielded 161 rushing yards and two touchdowns to Antwan Raymond a week ago. We're getting the starting running back for a heavily favored Buckeyes team (-23.5) at a sub-$7,000 price tag. Count me in.
Kevorian Barnes, TCU ($5,900) vs. Colorado - if he plays
Barnes is the starting running back for the Horned Frogs if he's healthy, but the question this week is whether he'll be healthy enough to give it a go or not. If he is, even at less than 100 percent, I'd take my chances here, as the matchup is one that may be too tough to pass up.
Colorado yielded 17-plus FD points to each of the first four running back rooms it faced and doesn't grade well.
Wide Receiver/Tight End
The Top Dogs
Bryant Wesco, Clemson ($10,200) at North Carolina
I almost included Cade Klubnik in the quarterback section above but elected against it. I still wouldn't be opposed to the pairing, but I think I lean a bit more toward Wesco here. My only fear is that Bill Belichick's MO throughout his coaching career has been to take away the top option, and that is clearly Wesco for the Tigers in this instance.
That said, UNC yielded 28-plus FD points to TCU and Charlotte in its first two games before facing FCS Richmond and a UCF squad that doesn't boast much of a passing attack. I can't quit the Clemson passing attack just yet, and Wesco is the most explosive of the bunch, yielding three straight 20-plus fantasy point games.
Chris Bell, Louisville ($9,400) vs. Virginia
Bell has seemingly claimed the top role in the receiver room for the Cards and actually leads the slate on the whole in target (39), and this is a matchup that figures to yield a fair amount of scoring on both sides. Caullin Lacy isn't that far behind with a 22.9 percent target share (32 total targets), but Lacy is a slot wideout who doesn't possess a ton of scoring upside, which is key in DFS on FanDuel. Bell has scored just twice himself, but I'd definitely put my money on him to be much more likely to find paydirt between the two of them Saturday, and Virginia has surrendered 37-plus fantasy points to each of the last two WR rooms it has faced.
Mid-Tier Targets
Zachariah Branch, Georgia 
($7,000) vs. Kentucky
Branch has settled into a comfortable role as a weapon for the Bulldogs this year, and he draws a good 6-7 touches per gam, whether it be as a receiver or a rusher. The matchup here doesn't seem the best, but the Bulldogs are going to have to score a number of times to reach that 34.5 implied total. In addition to his offensive contributions, Branch has the added bonus of being a returner, so there's also the outside chance he breaks one and adds a touchdown in that way as well. I'm not counting on that if I'm taking him, though. The Wildcats have yielded only two passing touchdowns to wide receivers through four games, so it's certainly risky, as Branch has only tallied double digits in games he's reached paydirt, but the secondary doesn't grade out the greatest.
Dre'lon Miller, Colorado 
($6,800) at TCU
What shouldn't go unnoticed here is that Miller saw significant run in the backfield last week due to injuries in CU's running back room. He handled eight carries in total, turning in 52 yards and a touchdown against BYU in addition to his two catches for 27 yards and a score as a receiver. With DeKalon Taylor and Simeon Price both out again, we could see a similar situation unfold involving Miller seeing work again back there Saturday. This should be a high-scoring affair with two uptempo teams going at it, and Miller figures to receive his fair share of touches.
Jordan Dwyer, TCU ($6,400) vs. Colorado
Dwyer has posted a pair of quiet games the last couple of times out, but lest ye forget the 24.1 FD points he posted against North Carolina in the opener and his 17.4 FD-point effort the following week versus FCS Abilene Christian. As mentioned above, McAlister is questionable for the contest, and it seems he's more likely to miss than not from what I've seen. Dwyer would seemingly slot in as the de facto No. 1 for the Horned Frogs this week. This is a great matchup and salary tag should that be the case, and he's likely still worth a shot even if a banged-up McAlister tries to play.
Bargain Options
Chris Marshall, Boise State ($5,600) at Notre Dame
Boise State is a heavy underdog in this one, so it figures to be a situation where the running game will need to be put into the back pocket at some point. Latrell Caples has posted the heaviest target share (19.4 percent) to date, but Marshall is explosive with his looks, averaging 10.8 yards per target, and he's coming off a seven-target showing against App State last time out. Marshall is one who could make a big play against the Fighting Irish and return the value needed in this one.
Dozie Ezukanma, TCU ($4,500) vs. Colorado - If Eric McAlister is out
Ezukanma saw his role increase last week after McAlister suffered an early injury against Arizona State, and McAlister looks to be highly questionable for Saturday's tilt as well. While the increased role only resulted in a catch for 17 yards on two targets a week ago, it came on short notice, and he should have more work under his belt with the starting unit in practice this week. Given the price tag and expected role, the redshirt freshman is worth a look.
Dallas Wilson, Florida ($4,500) vs. Texas
The matchup here is rough, but Wilson is a talented true freshman who was expected to win a starting job out of fall camp before an injury sidelined him. He'll finally make his debut here and comes in at a minimum price, so he may be worth a shot on a Gators offense looking for an infusion of offense after scoring a combined 17 points in its last two games.
Also Consider: T.J. Moore, Clemson ($5,500) at North Carolina
