College Football DFS: Week 10 Saturday Night Slate Picks and Strategy for DraftKings and FanDuel

We have a one-game discrepancy between the Saturday evening CFB slates on DraftKings and FanDuel, so we'll handle the outlier game at the end of the article. In the meantime, we'll take a look at the eight shared games and determine our best DFS endorsements for those contests.

CFB Saturday Night Week 10 Slate Overview

We managed to touch on every game except for the Arizona-Colorado matchup, but the total is decent and you're free to peruse those rosters if you like.  I was also not very fond of that the FSU/Wake game had to offer. As you'll see, I'm high on USC and Ole Miss on this slate, and I am to stack them both in most of my lineups. I also have pieces of Tenneseee, Oklahoma and Auburn, and one pick each for Washington State and N.C. State.

Weather Report

OREST/WSU - 60 percent chance of rain

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Quarterback

 Trinidad Chambliss, Mississippi (DK $9,300, FD $11,200) vs. South Carolina

It doesn't matter how you crunch it - Chambliss projects as my favorite quarterback for tonight's slate. The Rebels are red-hot, and they'll likely face a Gamecock squad that's ready to compete. There will be a lot of back-and-forth in this matchup. South Carolina has had success against most quarterbacks, but Diego Pavia and Garrett Nussmeier smoked this defense. Those players represent two very different styles of play, and one could argue that Chambliss offers a little bit of both. He's the best runner of the trio, and arguably the best passer on paper. Next to Ty Simpson, Chambliss should be one of South Carolina's toughest tests at quarterback.

Jayden Maiava, USC (DK $9,000, FD $10,800) @ Nebraska

This is a great spot for Maiava and USC's blue-chip offense. The Trojans were banged up a bit on the offensive line, but the bye week gave the front some time to heal, and most of them are expected back this week. That'll up the protection significantly for Maiava, who has a stellar group of playmakers to connect with. We'll talk about a couple of them shortly.

Also consider: If he is the starter, take Auburn's Ashton Daniels (DK $7,000, FD $8,700) against Kentucky as a QB flier.

Running Back

King Miller, USC (DK $7,900, FD $7,600) @ Nebraska

While Miller's sample size isn't large after taking over USC's lead running back role, he could finish the day as one of the most productive runners in the player pool. Nebraska's run defense ranks near the bottom of the FBS, and an improved outlook for USC's offensive line combines for a great outlook for Miller, who is getting twice as many snaps as Bryan Jackson. Look for Miller on first down early and often.

Jeremiah Cobb, Auburn (DK $7,000, FD $8,200) vs.Kentucky

Regardless of who ends up under center for the Tigers, they will attempt to lean on the running game against Kentucky. Cobb's number can sometimes be a little shaky, but he registered excellent totals against Mizzou and Arkansas over the past two weeks. Kentucky's run defense is horrible by comparison, spelling a potentially high ceiling for Cobb and the rest of the offense.

Also consider: Kewan Lacy, Mississippi (DK $7,000, FD $10,300) vs. South Carolina

Wide Receiver

Ja'Kobi Lane, USC (DK $6,500, FD $7,300) @ Nebraska

Taking Lane is nothing against Makai Lemon (DK $7,200, FD $10,800). I just doubt we can afford him, especially on FanDuel. Lane's size and speed are an equal headache for opposing quarterbacks, and he's a perfect stack for Maiava if you are choosing that avenue. Tanook Hines (DK $3,300, FD $5,400) is another USC wideout who has made some noise recently, but I don't think we need to reach that low.

Isaiah Sategna, Oklahoma (DK $6,900, FD $9,200) @ Tennessee

I don't trust John Mateer entirely, but I think he'll have plenty of pass volume and should get it to Sategna, who has been his preferred target over the past couple of weeks. He has other options to choose from, but I will take the recent data and rely on Sategna's potential target share.

Keenan Jackson, N.C. State (DK $3,400, FD $5,300) vs Georgia Tech

Jackson is my budget wideout pick tonight. If Justin Joly is out as expected, CJ Bailey will have to seek out other options. Jackson is his preferred target after Joly, and Georgia Tech has a beatable secondary that Bailey can exploit. He's a high-variance play, but we need the salary relief, and the injury spot is a great way to get it.

Also consider: Chris Brazzell, Tennessee (DK $6,200, FD $9,300) vs. Oklahoma,  Josh Meredith, Washington State (DK $5,600, FD $7,400) @ Oregon State

Michigan @ Purdue (FanDuel)

My first pick off the board for this game would have to be Jordan Marshall ($8,100). I have no problem with Justice Haynes, but I feel like Marshall will take on a lrger role in what could be a lopsided affair. I'm not very high on quarterbacks for this slate, as there may be a change at quarterback for Purdue, and Bryce Underwood doesn't inspire much confidence. I could go deeper in this game, but based on what is already available elsewhere, I don't see a pressing need.