Chris Godwin, Aaron Jones, Dak Prescott and numerous other fantasy standouts are lined up for unrestricted free agency, setting the stage for many high-stakes negotiations.
Davante Adams was the league's most unstoppable wide receiver in 2020, but he'll face his greatest test yet against the league's best corner in Jalen Ramsey.
Although there are plenty of interesting running back prospects in the 2021 draft, Travis Etienne is unchallenged as the RB1 until further notice.
With Ben Roethlisberger back in at quarterback Diontae Johnson should see his target volume spike back upward against a reeling Cleveland defense.
Justin Herbert concluded his excellent rookie season with his third four-touchdown game, and the pieces are in place for the Chargers offense to reach another level in 2021.
Justin Jefferson took the NFL by storm and Ja'Marr Chase might be even better, but Terrace Marshall is yet another LSU receiver we might see in the first round.
Jared Goff suffered a broken thumb during Sunday's loss to Seattle, leaving his Week 17 status in question with John Wolford as the on-call replacement.
Allen Robinson didn't need any help, but the tanking Jaguars look poised to give it to him anyway as the Bears head to Jacksonville.
The Vikings are touchdown underdogs as they head to the Superdome, setting the stage for rookie phenom Justin Jefferson to play a visible role in his homecoming to Louisiana.
Dennis Gardeck was a non-prospect out of Sioux Falls, but the formerly obscure third-year player has quickly established himself as an intimidating pass rusher.
Clyde Edwards-Helaire's return to Louisiana cruelly concluded with a somewhat concerning hip injury, while Jalen Hurts impressed again in his second start.
The Bears struggled against Justin Jefferson the first time around, and they might have a rough go of it again potentially down two of their top three cornerbacks Sunday.
With Justin Reid (thumb) headed to IR, Lonnie Johnson should step into a three-down role for the remainder of Houston's season.
The Raiders defense can make a lot of players look good, but Jonathan Taylor's breakout game Sunday was a welcome one all the same.
Beast or not, DeAndre Hopkins might have some trouble against James Bradberry, especially as defenses increasingly catch on to Arizona's static route combinations.
The Bengals have slowly but steadily worked in reps for third-round pick rookie Logan Wilson all year, but his workload has increased the last two weeks.
Just when it seemed like he couldn't fall any further, Carson Wentz found himself on the bench and Jalen Hurts in to replace him late in Sunday's loss to Green Bay.
The Packers might not need him much to secure the victory, but if they look to Allen Lazard he will pose a big mismatch against Philadelphia's tiny corners.
The Dallas defense isn't any good, but it might have found itself a good starter in second-year safety Donovan Wilson, who's been a DB1 since entering the starting lineup.
Austin Ekeler returned to the field against the Bills after a seven-game absence and immediately took up a starring role in the Justin Herbert offense.
After a two-week lull, Jamison Crowder might see his target volume spike upward against a Dolphins defense that's better outside than in the slot.
It was a slow start to the season for eighth overall pick Isaiah Simmons, but Week 10 marked a potential breakout point for the former Clemson star.
A torn ACL on Sunday ended what was otherwise a promising and productive rookie year for Joe Burrow, who finishes 2020 with 16 touchdowns (three rushing) in just under 10 games.
It's been a disappointing season for Marquise Brown and the Ravens offense, but Brown might not see an easier matchup all year than the Titans defense.
After previously spending his NFL career as a pass-rushing DE/OLB tweener, Collins has mostly shed the pass-rushing reps in Detroit and is piling up tackles instead.
The Saints got their victory, but a ribs injury to Drew Brees has their short-term quarterback situation up in the air for now.
The red-hot Keenan Allen has to slow down eventually, but with weak slot coverage and competent boundary coverage the Dolphins might funnel another healthy workload toward him in Week 10.
Playing in Landon Collins' former position, rookie seventh-round pick Kamren Curl should offer starting utility in all IDP formats going forward.
It didn't take long Sunday for Christian McCaffrey to settle any concerns about his ankle, but he picked up a new rib concern before the game's conclusion.
Few cornerback rotations are as ill-suited to stopping Allen Robinson as the shorthanded and shuffling Titans in Week 9.
After functioning mostly as an run-anchor defender in his first six NFL seasons, Stephon Tuitt has broken out to make a pass-rushing impact more like standout teammate Cameron Heyward in 2020.
Dalvin Cook had one of the best fantasy football box scores of recent memory Sunday, scoring four touchdowns and leading the Vikings to a road upset over Green Bay.
Few defenders hold as much sway over the Week 8 slate as Jaire Alexander -- he could shut down either of Adam Thielen or Justin Jefferson, but the one he doesn't cover should be open.
Atlanta's Foyesade Oluokun might look like a safety at around 6-2, 215, but his tackle totals are about as big as any linebacker in the game at the moment.
Aaron Rodgers needed a strong Week 7 bounce back after imploding against the Buccaneers in Week 6, and a four-touchdown showing against Houston should suffice.
Rarely does a receiver have as good of an on-paper matchup as Terry McLaurin against the hapless yet uptempo Cowboys -- both efficiency and volume appear close to ideal.
The injury to Benardrick McKinney was a big loss for the Houston defense, but Tyrell Adams appears to have emerged as a standout IDP in his absence.
Peak Derrick Henry normally shows up in November, but his 212 yards rushing in Week 6 may have heralded an early arrival in 2020.
Preston Williams broke out in Week 5 and might keep it rolling in Week 6 against the Jets, whose strong slot coverage encourages offenses to target their weak outside corners.
He's not exactly central casting's idea of an intimidating NFL pass rusher, but in 2020 quarterbacks are learning to fear the 5-foot-9, 184-pound Mike Hilton.
Dak Prescott cruelly suffered a season-ending ankle injury against the Giants, casting a cloud over a day that was somewhat eventful otherwise.
It's been a disheartening season for the Giants offense, but they might get on track as Darius Slayton and company take on a struggling Dallas secondary.
Trey Hendrickson is off to a fast start for the Saints, but there will only be so many snaps to go around between Hendrickson, Cam Jordan and the imminently returning Marcus Davenport.
In a day with several discouraging injuries, a knee injury to Nick Chubb may prove the headliner, pending MRI results.
With nicked up and aging corners set to face off against him, D.J. Moore is in a bounce-back spot against the uptempo Cardinals.
After two quiet years disrupted by injury, Carl Lawson has reemerged as potentially the most feared pass rusher on a Cincinnati defense with several standout linemen.
With a five-touchdown showing in a high-stakes win against a good defense Sunday, Josh Allen appears to have turned a corner in his quarterback development.
The Panthers have largely foregone the slot corner position in two games, choosing to cover with linebackers and safeties -- a potentially risky strategy against Keenan Allen.
Although the Minnesota defense regressed going into 2020, fewer third-down stops for the defense means more snaps and tackles for Eric Kendricks.
In a day full of frustrating injuries, a suspected season-ending torn ACL suffered by Saquon Barkley stands out as especially painful.