This article is part of our DraftKings MLB series.
Jon Lester, CHC at OAK ($9,600): Lester has already matched last season's 11 wins, and the one-time Oakland rental will be heavily favored to exceed that mark against his former team. Opposing starter Dillon Overton has a 9.33 ERA through four major league starts, so Lester will likely have a cakewalk to victory lane if he can just hold the league's ninth-worst offense in check. That isn't asking much, given that he'll be pitching in baseball's fifth-most pitcher-friendly park coming off a strong outing in which he hurled six shutout innings against a much more capable Seattle team. You'd be foolish not to take advantage of this colossal mismatch on the mound.
Dallas Keuchel, HOU vs. TEX ($8,100): When Minute Maid park gives him lemons, Keuchel makes lemonade. After posting a sparkling 1.46 ERA there last season, the southpaw has once again been markedly better at home with a 3.66 ERA compared to 5.74 on the road. That number has been steadily trending downwards over his last four home appearances, in which he has given up just seven runs in 27.2 innings for a 2.28 ERA. This feels like a must-have game for the Astros if they want to chase down Texas in the race for the AL West, and Keuchel's strong early career resume in the clutch compares nicely to the Rangers' spotty history in such situations over the past few years. Take advantage of a price that has been artificially driven down by bad luck all season (.314 BABIP and career-low 67.4 percent strand rate), and don't be scared of an offense that has mustered a mere 15 runs in its last five games.
Kurt Suzuki, MIN at TB ($3,000): Suzuki has been low-key effective against lefties, posting a .353 wOBA in 79 plate appearances. The catcher's consistent offensive success has earned him a recent promotion to the more fruitful five-spot in the Twins' order, and he should be able to reward manager Paul Molitor's decision against Rays rookie Blake Snell, who has a 4.26 ERA and is allowing a .381 OBP at home. Between Snell's poor performance at Tropicana Field and Suzuki's affordability, the veteran makes for a great low-cost choice that allows you to spend big elsewhere.
Pedro Alvarez, BAL at CHW ($3,600): Alvarez offers all the upside of the bigger names at the position at a fraction of the cost. With four homers in his last four games and 13 since Jun. 2, the streaking slugger is worth a long look against former Orioles starter Miguel Gonzalez. Alvarez has a respectable .359 wOBA against right-handed pitchers, with 27 of his 28 extra-base hits coming in that split. Meanwhile, the middling righty sports a pedestrian 4.06 ERA and has been markedly worse at U.S. Cellular Field than on the road all year.
Jason Kipnis, CLE at NYY ($4,200): Kipnis has a robust .369 wOBA against right-handed pitching this season, which bodes well for his chances of finding success against Michael Pineda at Yankee Stadium. Left-handed bats have tagged Pineda for a .346 wOBA overall, and the struggling starter has given up at least five runs in three of his last five appearances. Those numbers, along with the venue's southpaw-friendly short porch in right field, play right into the second baseman's hands.
Kris Bryant, CHC at OAK ($5,200): In case you missed it earlier, Oakland starter Dillon Overton's big-league career is off to an atrocious start. The first 74 right-handed hitters to face him have managed a .493 wOBA, and Bryant is far from your average righty bat. The young third baseman has posted an elite .418 wOBA against lefties this season, so expect nothing less than another stellar performance against this subpar one.
Francisco Lindor, CLE at NYY ($3,600): Lindor has been on a torrid pace over the past month, having hit safely in 20-of-24 games while scoring 19 runs. The switch-hitting shortstop has displayed roughly equal effectiveness from both sides in that time, and he comes in as confident as ever after smashing his 13th homer of the year Thursday. Yankee starter Michael Pineda's struggles against left-handed bats were already documented, and he'll get no reprieve with this lineup as Lindor will be facing him from the left side immediately after Kipnis.
Aaron Altherr, PHI at SD ($2,900): Altherr has been hit-or-miss since making his season debut on Jul. 28, but his good performances have been so impressive that it's hard to ignore him at just $2,900. The young outfielder already has a pair of three-hit games under his belt, and his combination of power and speed have allowed him to accrue two homers, three steals, six runs and nine RBI in seven appearances. He's been batting in the No. 2 slot for a Phillies offense that has picked it up of late, and faces a creampuff pitching matchup in lefty Christian Friedrich (6.92 ERA in his last eight starts).
Charlie Blackmon, COL vs. MIA ($5,400): Runs should be plentiful with Colorado's high-octane lineup facing mediocre starter David Phelps, who has a career 4.10 ERA and will be transitioning from a bullpen role following the trade-back of injured starter Colin Rea to San Diego. The Marlins' best-case scenario still involves a short outing from Phelps, so Blackman should also get some opportunities against their bullpen as he looks to add to the 10 hits and eight runs he has amassed over the last six games. Chances are Blackmon will already be having a successful game by that point anyway given his .363 wOBA against right-handers.
Lorenzo Cain, KC vs. TOR ($4,200): Cain is once again hitting lefties hard, posting a .434 wOBA this season after topping .400 in 2015. Debuting Blue Jay Francisco Liriano struggled to a 5.46 ERA in Pittsburgh, and Kansas City's hitter-friendly Kauffman Stadium will be even less forgiving to his mistakes. Since right-handed hitters in general have posted a .357 wOBA against Liriano, the incredibly proficient Cain is likely to have a field day in this matchup.