Matt Harvey, NYM vs. ATL ($8,100): The pitching pool is shallow Thursday, and Harvey has at least shown to be an elite hurler in the past (25.1 strikeout percentage and 2.79 FIP for his career). It's also encouraging that he's been touching the high-90s lately. Atlanta's lineup might not be a complete pushover, but they've done nothing through the first two games of the season and posted a .308 wOBA against right-handed arms last year.
Blake Snell, TB vs. TOR ($7,100): The Blue Jays haven't got going offensively yet and have scored just three runs through their first two games. So, while Toronto fared well against southpaws last year 12th-ranked .324 wOBA), this might be a sneaky spot for Snell's pitch movement to keep the Jay Birds in a funk. Plus, Snell posted a solid 24.4 strikeout percentage and 3.39 FIP through 19 starts as a rookie last year.
Evan Gattis, HOU vs. SEA ($3,900): There's feast and famine in Gattis' approach, but he posted solid numbers last season against lefties with a .256 ISO and .366 wOBA. Ariel Miranda's made just 10 career starts, and for what it's worth, he struggled this spring (6.14 ERA and 1.54 WHIP). Beginning 2017 against the potent 'Stros doesn't bode well.
Joey Votto, CIN vs. PHI ($5,000): Clay Buchholz will need all his veteran savvy to deal with Votto. The first baseman owned right-handed pitchers to the tune of a 1.033 OPS, .254 ISO and .429 wOBA last year, so with Buccholz's allowing a 35.8 hard-hit percentage and .342 wOBA to lefties in 2016, the batter should trump the arm.
Jose Altuve, HOU vs. SEA ($4,900): With a .391 on-base percentage and .378 wOBA against lefties, Altuve offers both a solid floor and high upside, and especially if you keep his speed in mind. Miranda posted a 5.57 FIP against right-handed hitters and allowed a 37.2 hard-hit percentage, so this is a worthwhile matchup to spend up for Altuve.
Kris Bryant, CHC at STL ($5,000): 0-for-9 to start the campaign, Bryant is looking for his 2017 breakout showing, and a matchup with Lance Lynn might be the answer. Lynn hasn't pitched since 2015, and Bryant posted a .239 ISO and .382 wOBA against right-handed arms last year. Hitting between Kyle Schwarber and Anthony Rizzo also helps Bryant's case.
Trevor Story, COL at MIL ($4,700): Chase Anderson allowed a 39.8 hard-hit percentage and .394 wOBA to right-handed hitters in 2016, and Story mashed righties with a .559 slugging percentage, .290 ISO and .369 wOBA. The fact that this isn't a traditional handedness advantage might keep Story's ownership in check, too.
George Springer, HOU vs. SEA ($4,500): A solid stack option alongside Jose Altuve and Evan Gattis, Springer's .286 ISO and .400 wOBA against southpaws makes him a strong option at this salary. His 28.6 HR/RB rate and 40.2 hard-hit percentage are equally gaudy marks.
Miguel Sano, MIN vs. KC ($4,100): There is a lot of hit or miss in Sano's game, and he checks out as a high-risk, high-reward option. That should keep Sano's ownership down, though, and the slugger owns a respectable .238 ISO and .356 wOBA against righties since entering the league. Jason Hammel allowed a 36.4 hard-hit percentage to right-handed hitters in the second half last year, too.
Joc Pederson, LAD vs. SD ($3,700): Hitting down the lineup can hurt Pederson's upside, but his track record against right-handed pitchers is impressive, and Jered Weaver isn't a deterrent. After all, Pederson posted a .364 wOBA against righties, and Weaver allowed a .552 slugging percentage and .365 wOBA to left-handed hitters last year.