Brandon Aiyuk's acceleration and ball-tracking skills could spell trouble for Kansas City's middling safeties, but first the Niners need to keep DL Chris Jones off of Brock Purdy.
Facing a tough defense with the bull's eye on him, Sunday's showdown with Buffalo will help clarify just how good Rashee Rice can be.
CeeDee Lamb could have one of his biggest games playing against a Lions defense that's tougher against the run than the pass.
DK Metcalf could pose a major big-play threat to Tennessee's injury-challenged corner rotation.
Isaiah Likely did his best Mark Andrews impression Sunday night, but the Baltimore offense took another hit with RB Keaton Mitchell suffering an ACL tear.
If New England prioritizes defending Travis Kelce then the Pats might not have leftover personnel to cover Rashee Rice.
Ja'Marr Chase should keep rolling against a Colts secondary with poor boundary corner personnel.
The Saints are tougher on the boundary than in the slot, which should provoke a big game from Amon-Ra St. Brown.
CeeDee Lamb has been a menace from the slot, where Washington lacks the coverage personnel to defend itself.
Playing at home and against the Bears, the Week 11 setup couldn't be much easier for Amon-Ra St. Brown.
DeAndre Hopkins should be able to get rolling against a struggling and injured Tampa Bay corner rotation.
The Vikings face a simple reality Sunday: either Jordan Addison has a strong game, or the Minnesota passing game falls apart.
It might be now or never for DeAndre Hopkins, who catches the Colts battered and weak at cornerback.
The Dolphins are looking to bring a shootout to the Bills, but Stefon Diggs is prepared to shoot back against Miami's questionable pass defense.
Erik Siegrist previews the Monday night matchups as Matthew Stafford and the Rams travel to Cincinnati in the nightcap.
Dan Marcus writes about the best IDP options for Week 3, starting in Buffalo where linebacker Terrel Bernard has been an excellent replacement for Tremaine Edward.
Drake London is due for a bounce-back after no catches in Week 1, but Jaire Alexander could deny it anyway.
The Colts' cornerback personnel is weak but their run defense is strong, setting up a feast for Calvin Ridley and the Jags passing game.