Atlanta United is a heavy favorite despite playing away to San Jose on Wednesday, which means fantasy players are likely to put their focus on Miguel Almiron.
Cristiano Ronaldo finally opened his account for Juventus with a brace last weekend, and he's looking to start a goal streak Wednesday at Valencia.
Napoli are big favorites away to FK Crvena Zvezda, which means fantasy players may be looking into stacking their high-scoring attack.
Los Angeles FC is heavily favored at home against the Revolution on Saturday, which means fantasy players will strongly consider paying up for Carlos Vela.
With Manchester City heavily favored at home against Fulham on Saturday, Sergio Aguero could be one of the highest-owned players in cash games and GPPs.
D.C. United have been rolling of late, and they have a great opportunity to keep it going Wednesday against a Minnesota United squad that has been horrific on the road this season.
Germany v. France is the highlight match of Thursday's three-game UEFA Nations League slate, but fantasy players can likely find plenty of production in the other two games as well.
New York City FC are heavily favored at home against the Revolution on Wednesday, but it won't be easy to pair their two biggest stars.
D.C. United are one of the hottest teams in Major League Soccer, but can they slow down Atlanta United's Josef Martinez, who has already set the league's single-season goal-scoring record?
Monterrey are solid favorites away to Puebla on Friday, but Tijuana and Morelia offer plenty as home favorites.
Bertrand Traore has two goals on 14 shots in his first three games, and he'll look to keep his active play going Friday at home to Nice.
Many fantasy players could focus on Manchester City as they host Newcastle at the Etihad Stadium, which means those who target Chelsea at home against Bournemouth could reap the benefits of their lower-owned attackers.
PSV Eindhoven are the biggest favorites on Wednesday's three-game slate, but fantasy players will have to decide how much they want to pay up for their stars.
Ajax have a commanding 3-1 aggregate lead over Dynamo Kyiv after the first leg in the Netherlands, and they are favored to win in Ukraine on Tuesday.
Paul Pogba has scored from the penalty spot in each of the first two matches this season, and he could be a popular GPP option Monday against Spurs.
First-place Cruz Azul visits third-place Santos Laguna on Sunday, but fantasy players may be better off focusing on Toluca at home against Leon.
Lyon are big favorites at home to Strasbroug on Friday, and Memphis Depay could be a very popular fantasy option.
Mohamed Salah figures to be a very popular play on Saturday's five-game slate, and while fantasy players could pivot to Sadio Mane, RotoWire's Andrew Laird explains why Roberto Firmino may be the better alternative.
Tigres are the biggest favorites on Wednesday's five-game slate, so fantasy players will have to decide if they want to pay up for Andre-Pierre Gignac.
Things always get heated during the Hudson River Derby, and New York City FC will need a big game from Maximiliano Moralez if they want to grab all three points.
Ajax are strong favorites at home to Dynamo Kyiv on Wednesday, which will put Hakim Ziyech under the fantasy spotlight.
PSV Eindhoven are favored away to BATE Borisov on Tuesday, but is it enough to make fantasy players pay up for Hirving Lozano?
Liverpool are favored away to Crystal Palace on Monday, which means fantasy players will face the tough decision about whether or not to fade Mohamed Salah.
Los Angeles FC is heavily favored at home against the Rapids on Sunday, but will fantasy players want to pay up for Carlos Vela?
Inter Milan open up their 2018/19 Serie A campaign away to Sassuolo, a match the odds makers expect Inter to handle comfortably.
Raul Rivero has taken the second-most shots among players on Friday's two-game slate, but he still hasn't found the back of the net. Will it happen at home against Morelia?
With Tottenham heavily favored at home against Fulham on Saturday, fantasy managers will have to decide whether it's optimal to choose one of Harry Kane or Christian Eriksen, or find enough value to roster both.
Zlatan Ibrahimovic has gotten on the scoresheet in nine consecutive starts, and he'll look to make it an even 10 on Tuesday at home against the Rapids.
Puebla are the big favorites on Friday's two-game slate, but with Morelia and Necaxa expected to be close, there could be plenty of fantasy points to be had.
Chelsea's Willian could be a popular cash-game target if he starts Saturday at Huddersfield, but RotoWire's Andrew Laird has a few other names worth considering for the five-game Premier League slate.