Injury hotspots for Week 10 include Arizona's defense (especially the CBs), Seattle's wide receivers, the Chargers' offensive tackles, Atlanta's guards, Houston's offensive line, the Colts' defensive line and San Francisco's front seven.
Below you'll find four different categories, with our lists including key offensive linemen and defensive players whose absences might impact fantasy decisions. The bottom section, for potential game-day decisions, is sorted by kickoff times. It can be used as a checklist/cheatsheet for Sunday morning and afternoon when inactives come out and we need to adjust lineups. Before we get to the 'questionable' players, let's see who's definitely in and who's definitely out...
Good to Go 💯
RB Saquon Barkley (groin)
RB James Cook (foot)
RB Rico Dowdle (quad)
RB Nick Chubb (foot)
RB Jacory Croskey-Merritt (tooth)
RBs Kyle Monangai (ankle) & Roschon Johnson (back)- WR A.J. Brown (hamstring)
WR Puka Nacua (chest)
WR Michael Pittman (glute)- WRs Rome Odunze (heel), DJ Moore (groin) & Luther Burden (concussion)
WR Zay Jones (knee) 
WR Dyami Brown (concussion)- TE Dalton Schultz (knee/shoulder)
TE Theo Johnson (shoulder)- TE Cole Kmet (concussion)
TE Darnell Washington (foot)
Ruled Out/Doubtful 🚑
Out/Doubtful/IR
QB Brock Purdy (Q - backup if active)- QB Jayden Daniels (left elbow)
- QB C.J. Stroud (concussion)
RB Rhamondre Stevenson (foot)
RB Bucky Irving (foot/shoulder)- WR Brian Thomas (high ankle)
- WR Ricky Pearsall (knee)
WRs Tory Horton (shin), Dareke Young (quad) & Jake Bobo (calf)- WRs Terry McLaurin (quad) & Luke McCaffrey (IR - collarbone)
- WR Kayshon Boutte (hamstring)
- WRs Chris Godwin (fibula) & Mike Evans (IR - collarbone)
WR Isaiah Bond (foot)- WR Beaux Collins (neck)
TE Josh Oliver (foot)- TE Hunter Long (hip/knee)
- K Ka'imi Fairbairn (quad)
- K Graham Gano (neck)
Potential Workload Beneficiaries (From Injuries Above)
- QB Mac Jones
- QB Marcus Mariota
- QB Davis Mills
- RBs TreVeyon Henderson & Terrell Jennings
- RB Rachaad White
- WRs Parker Washington, Dyami Brown & Jakobi Meyers
- WR Kendrick Bourne
- WRs Rashid Shaheed, Cooper Kupp & Cody White
- WRs Chris Moore & Jaylin Lane
- WR Kyle Williams
- WR Tez Johnson & Sterling Shepard
- WR Cedric Tillman
- TE Johnny Mundt
Key Defensive Players + Offensive Linemen
- CB Will Johnson (back), CB Max Melton (head), LB Mack Wilson (ribs)
- CB Paulson Adebo (knee), LB Darius Muasau (ankle), C John Michael Schmitz (shin)
- LB Ernest Jones (D - knee), CB Josh Jobe (concussion)
DE Chop Robinson (concussion)- LB Christian Elliss (hip)
- LB T.J. Edwards (hand)
- DT DeForest Buckner (IR - neck), DE Samson Ebukam (knee), DE Tyquan Lewis (groin)
CB Tarheeb Still (knee) + RT Bobby Hart (knee) + LT Joe Alt (IR - ankle)- CB Jourdan Lewis (neck), G Ezra Cleveland (knee)
- OLB Haason Reddick (ankle)
- LB Christian Harris (shin), DB Jalen Pitre (head)
- RT Tytus Howard (concussion), RG Ed Ingram (knee)
- G Isaac Seumalo (pectoral)
LG Matthew Bergeron (ankle)
RT Taliese Fuaga (ankle)
More on the #Texans being set to miss five starters, including C.J. Stroud, against the #Jaguars on Sunday.https://t.co/pcUFCGkn55 via @houstonchron
— Sam Warren (@samwarren_3) November 7, 2025
Listed as Questionable - Should Play 👍
- RB D'Andre Swift (groin/personal)
WR Garrett Wilson (knee)- WR Cooper Kupp (hamstring)
- TE AJ Barner (calf)
- WR Cedric Tillman (IR - hamstring)
#Jets injury report: Garrett Wilson listed as questionable, but he was full practice and will play. No injury designation for Tyrod Taylor, presumptive backup. pic.twitter.com/GK68rq9o4H
— Rich Cimini (@RichCimini) November 7, 2025
Ben Johnson gives some insight into how the Bears will divvy up their backfield with both D'Andre Swift and Kyle Monangai set to play: "I believe in a guy having the hot hand. One guy, if he's feeling it and giving us a spark, we might lean on that a little bit longer."
— Courtney Cronin (@CourtneyRCronin) November 7, 2025
Cooper Kupp and A.J. Barner were both full participants at practice on Friday. Mike Macdonald sounded optimistic that both players would be able to play on Sunday.
— Curtis Crabtree (@Curtis_Crabtree) November 7, 2025
Truly Questionable / Game-Time Decisions 🤔
Early Games
- RB Aaron Jones (shoulder/toe)
- WR Tetairoa McMillan (hamstring)
- RB Ollie Gordon (ankle)
- RB Alvin Kamara (ankle)
- TE Harold Fannin (hamstring)
Vikings RB Aaron Jones didn't return to last week's win at Detroit after suffering an AC joint sprain in the third quarter, but he managed limited practice participation Thursday and Friday this week, saying afterward that he's improving and may be ready by Sunday. It sounds pretty 50/50 to me, with Jones potentially coming down to a game-time decision. If he doesn't play, Zavier Scott will jump in on passing downs while Jordan Mason gets another shot as the lead runner.
Vikings RB Aaron Jones (shoulder/questionable) on if he's feeling good about his chances to play Sunday: "I do feel good. Continue to take it each day. I still have two days, so I feel like I'll be in a good spot." Jones was limited in practice Thursday and Friday.
— Kevin Seifert (@SeifertESPN) November 7, 2025
Panthers WR Tetairoa McMillan was an end-of-week addition to the injury report after leaving Friday's practice early due to a hamstring injury. Panthers coach Dave Canales didn't seem to think it's serious but did acknowledge that there's concern for McMillan's availability this Sunday. If the rookie doesn't play, Xavier Legette and Jalen Coker will take on more prominent roles in a feeble passing game.
#Panthers Dave Canales on Tetairoa McMillan's hamstring flaring up on him today below.
Brycen Tremayne is also questionable. When asked later if Hunter Renfrow is next up, Canales acknowledged the possibility but said that's something the team will determine closer to game time. https://t.co/7RC0uoivDz pic.twitter.com/DDgkeVAkKF
— Alex Zietlow (@alexzietlow05) November 7, 2025
Saints RB Alvin Kamara should be fine to play through his ankle injury again, while Browns TE Harold Fannin (hamstring) is a mystery after being added to the injury report Thursday (as 'DNP') and returning to limited participation Friday. Devin Neal and David Njoku are the obvious beneficiaries if either of those guys doesn't play.
Late-Afternoon Games
- WR Jordan Whittington (back)
Primetime Games
WRs Matthew Golden (knee), Dontayvion Wicks (calf) & Malik Heath (hip)
Green Bay's WR situation got murkier Friday, with Golden downgrading to non-participation and Heath added to the injury report. Romeo Doubs and Christian Watson (knee) appear fine, however, and they're the top two guys right now, in any case. The No. 3 job does matter more with Tucker Kraft (ACL) out for the season, but a matchup with Philadelphia's secondary is suboptimal.
Key Defensive Players + O-Linemen
- RG Chris Lindstrom (foot)
- CB Christian Benford (groin), CB Taron Johnson (groin)
- CB Rasul Douglas (foot), S Ashtyn Davis (quad)
- S Jevon Holland (knee), RT Jermaine Eluemunor (pectoral)
- LB Dee Winters (knee), DT Kalia Davis (ankle), DT Alfred Collins (hip), LB Tatum Bethune (thigh)
- CB Adoree' Jackson (concussion)
